功能性光学相干断层扫描能够对因视网膜变性导致的光感受器功能障碍进行视网膜电图检查。
Functional optical coherence tomography enables optoretinography of photoreceptor dysfunction due to retinal degeneration.
作者信息
Kim Tae-Hoon, Wang Benquan, Lu Yiming, Son Taeyoon, Yao Xincheng
机构信息
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, VA 20147, USA.
出版信息
Biomed Opt Express. 2020 Aug 27;11(9):5306-5320. doi: 10.1364/BOE.399334. eCollection 2020 Sep 1.
Abstract
Stimulus-evoked intrinsic optical signal (IOS), which occurs almost immediately after the onset of retinal stimulus has been observed in retinal photoreceptors, promises to be a unique biomarker for objective optoretinography (ORG) of photoreceptor function. We report here the first-time ORG detection of photoreceptor dysfunction due to retinal degeneration. A custom-designed optical coherence tomography (OCT) was employed for longitudinal ORG monitoring of photoreceptor-IOS distortions in retinal degeneration mice. Depth-resolved OCT analysis confirmed the outer segment (OS) as the physical source of the photoreceptor-IOS. Comparative ERG measurement verified the phototransduction activation as the physiological correlator of the photoreceptor-IOS. Histological examination revealed disorganized OS discs, i.e. the pathological origin of the photoreceptor-IOS distortion.
摘要
刺激诱发的内在光学信号（IOS）几乎在视网膜刺激开始后立即出现在视网膜光感受器中，有望成为用于光感受器功能客观视网膜电图（ORG）的独特生物标志物。我们在此报告首次对视网膜变性导致的光感受器功能障碍进行ORG检测。采用定制设计的光学相干断层扫描（OCT）对视网膜变性小鼠的光感受器IOS畸变进行纵向ORG监测。深度分辨OCT分析证实外段（OS）是光感受器IOS的物理来源。比较性视网膜电图测量验证了光转导激活是光感受器IOS的生理相关因素。组织学检查揭示了OS盘紊乱，即光感受器IOS畸变的病理起源。
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