Son Taeyoon, Kim Tae-Hoon, Ma Guangying, Kim Hoonsup, Yao Xincheng
Department of Bioengineering, University of Illinois at Chicago, Chicago, IL 60607, USA.
Department of Ophthalmology and Visual Sciences, University of Illinois at Chicago, Chicago, IL 60612, USA.
Exp Biol Med (Maywood). 2021 Mar;246(6):639-643. doi: 10.1177/1535370220978898. Epub 2020 Dec 13.
Functional mapping of photoreceptor physiology is important for better disease diagnosis and treatment assessment. Fast intrinsic optical signal (IOS), which arises before light-evoked pupillary response, promises a unique biomarker of photoreceptor physiology for objective optoretinography with high resolution. This study is to test the feasibility of non-mydriatic IOS mapping of retinal photoreceptors in awake human. Depth-resolved optical coherence tomography verified outer segment (OS) as the anatomic origin of fast photoreceptor-IOS. Dynamic IOS changes are primarily confined at OS boundaries connected with inner segment and retinal pigment epithelium, supporting transient OS shrinkage due to phototransduction process as the mechanism of the fast photoreceptor-IOS response.
光感受器生理学的功能图谱对于更好地进行疾病诊断和治疗评估至关重要。快速内在光信号（IOS）出现在光诱发的瞳孔反应之前，有望成为用于高分辨率客观视网膜成像的独特光感受器生理生物标志物。本研究旨在测试在清醒人类中对视网膜光感受器进行不散瞳IOS图谱绘制的可行性。深度分辨光学相干断层扫描证实外段（OS）是快速光感受器IOS的解剖学起源。动态IOS变化主要局限于与内段和视网膜色素上皮相连的OS边界，支持光转导过程导致的OS瞬时收缩作为快速光感受器IOS反应的机制。
