Deryugina A V, Danilova D A
N. I. Lobachevsky National Research State University of Nizhny Novgorod, Nizhny Novgorod, Russia.
Bull Exp Biol Med. 2023 Aug;175(4):433-436. doi: 10.1007/s10517-023-05880-5. Epub 2023 Sep 29.
We studied the effect of molecular hydrogen H on the content of circulating endothelial cells and the macrohistological structure of the heart in rats with simulated chronic heart failure. Inhalation with 2% H was carried out repeatedly (40 min per day for 5 consecutive days) or once (40 min). Molecular hydrogen inhalations in both regimens caused a decrease in the number of circulating endothelial cells; the most pronounced effect was observed after repeated inhalations on day 14 after chronic heart failure modeling. The decrease in the count of circulating endothelial cells under the action of H was accompanied by recovery of the myocardial structure and a decrease in its weight. Molecular hydrogen in chronic heart failure limited the damage to endothelial cells and improved the structure of rat myocardium, which allows us to consider H inhalations as the means reducing the progression of chronic heart failure.
我们研究了分子氢（H₂）对模拟慢性心力衰竭大鼠循环内皮细胞含量及心脏大体组织结构的影响。采用2% H₂进行反复吸入（每天40分钟，连续5天）或单次吸入（40分钟）。两种方案的分子氢吸入均导致循环内皮细胞数量减少；在慢性心力衰竭建模后第14天反复吸入后观察到最明显的效果。在H₂作用下循环内皮细胞计数的减少伴随着心肌结构的恢复及其重量的减轻。慢性心力衰竭中的分子氢限制了内皮细胞损伤并改善了大鼠心肌结构，这使我们能够将H₂吸入视为减缓慢性心力衰竭进展的手段。
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