Altern Ther Health Med. 2024 Jan;30(1):102-110.
A large proportion of patients undergoing assisted reproductive therapy (ART) suffer from premature ovarian insufficiency (POI). The knowledge structure, research hotspots, and research trends related to ART for patients with POI are still unclear and have not been systematically summarized. We aimed to analyze the research status of ART for patients with POI and deeply explore its knowledge structure and research trends. Our findings may provide treatment recommendations for clinicians and guidance for researchers in further research.
The PubMed database for publications on ART for patients with POI was searched. The Bibliographic Item Co-occurrence Matrix Builder (BICOMB) obtained the Co-word matrix and co-occurrence matrix. The H-index method was used to extract high-frequency main Medical Subject Headings (MeSH) terms/subheadings. Then we used software such as graphical clustering toolkit (gCluto), Microsoft Excel, Ucinet and NetDraw to carry out the biclustering analysis, strategic diagram analysis and social network analysis of the major MeSH terms/subheadings.
The high-frequency major MeSH terms/subheadings were analyzed by biclustering, strategic diagram, and social network analyses. A total of 431 articles from 1983 to 2023 were retrieved. Analysis showed that a total of 176 journals published relevant papers, including FERTILITY AND STERILITY, ranking first. In addition, we extracted 20 high-frequency major MeSH terms/subheadings. We grouped them into five categories: cryopreservation of oocyte and ovarian tissue, oocyte donation, in vitro activation (IVA) of primordial follicles, overview of therapy for patients with POI, therapy of iatrogenic POI. Within these five categories, there were 4, 4, 3, 4, and 5 major MeSH terms/subheadings, respectively. The major MeSH terms/subheadings were evenly distributed, and no particular group had a particular central tendency.
The therapy of Iatrogenic POI is in the core position of research and is becoming increasingly mature. Oocyte donation and IVA of primordial follicles are the trends of future research. This study is helpful to understand the current research status, knowledge structure, and research trends of ART for patients with POI, and provide reference for improving ART for patients with POI in the future. Our study may guide clinicians to apply more established research to treat patients, which may lead to better treatment outcomes for patients. At the same time, we also suggest that researchers can conduct research in the field of future research trends, which may lead to greater research results.
接受辅助生殖技术（ART）的患者中有很大一部分患有卵巢早衰（POI）。关于 POI 患者的 ART 的知识结构、研究热点和研究趋势仍不清楚，尚未进行系统总结。我们旨在分析 POI 患者 ART 的研究现状，并深入探讨其知识结构和研究趋势。我们的研究结果可能为临床医生提供治疗建议，并为进一步研究的研究人员提供指导。
检索 PubMed 数据库中有关 POI 患者 ART 的出版物。Bibliographic Item Co-occurrence Matrix Builder（BICOMB）获得共词矩阵和共现矩阵。使用 H 指数法提取高频主要医学主题词（MeSH）词/副主题词。然后使用图形聚类工具包（gCluto）、Microsoft Excel、Ucinet 和 NetDraw 等软件对主要 MeSH 词/副主题词进行双聚类分析、战略图分析和社会网络分析。
通过双聚类、战略图和社会网络分析对高频主要 MeSH 词/副主题词进行分析。共检索到 1983 年至 2023 年的 431 篇文章。分析表明，共有 176 种期刊发表了相关论文，其中排名第一的是《生育与不孕》。此外，我们还提取了 20 个高频主要 MeSH 词/副主题词。我们将它们分为五类：卵母细胞和卵巢组织的冷冻保存、卵母细胞捐赠、原始卵泡的体外激活（IVA）、POI 患者治疗概述、POI 的治疗。在这五类中，分别有 4、4、3、4 和 5 个主要 MeSH 词/副主题词。主要 MeSH 词/副主题词分布均匀，没有特定的组有特定的中心趋势。
POI 的治疗已成为研究的核心，且日趋成熟。卵母细胞捐赠和原始卵泡的 IVA 是未来研究的趋势。本研究有助于了解 POI 患者 ART 的当前研究现状、知识结构和研究趋势，并为未来改善 POI 患者的 ART 提供参考。我们的研究可能有助于指导临床医生应用更成熟的研究来治疗患者，从而为患者带来更好的治疗效果。同时，我们还建议研究人员可以在未来研究趋势领域进行研究，这可能会带来更大的研究成果。
