Horsfall P A, Plummer J, Allan W G, Girling D J, Nunn A J, Fox W
Tubercle. 1979 Mar;60(1):13-24. doi: 10.1016/0041-3879(79)90051-5.
Chinese patients with arthralgia during treatment with an antituberculosis regimen containing pyrazinamide were allocated at random to 3 anti-arthralgia treatment series in a controlled double-blind study. One series (18 patients) received soluble aspirin 2.4 g daily, the second (23 patients) allopurinol 200 mg daily, and the third (19 patients) placebo only, for 8 weeks. The response was assessed both by independent assessors and by the patients themselves using a diary card. The serum uric acid concentration was measured before and during anti-arthralgia treatment. The joints most commonly affected were the shoulders, the knees and the fingers, and symptoms and signs were in general neither severe nor protracted. For most of the patients in all 3 series the joint symptoms and signs improved during the 8 weeks, but a higher proportion of patients in the aspirin and placebo series than in the allopurinol series experienced improvement, this being most rapid in the aspirin series. Only in the aspirin series was the mean serum uric acid concentration lower during treatment than before it, and this effect was related to the dose in mg per kg. It is concluded that the arthralgia was often self-limiting, that aspirin had a small beneficial effect, that allopurinol, in the dosage studied, may have had a slightly deleterious effect, but that it would be worth studying larger dosages of allopurinol because the dosage studied did not affect the serum uric acid concentration.
在接受含吡嗪酰胺的抗结核治疗方案治疗期间出现关节痛的中国患者，被随机分配到3个抗关节痛治疗组，进行一项对照双盲研究。一组（18例患者）每日服用可溶性阿司匹林2.4克，第二组（23例患者）每日服用别嘌醇200毫克，第三组（19例患者）仅服用安慰剂，为期8周。由独立评估人员以及患者本人使用日记卡对疗效进行评估。在抗关节痛治疗前及治疗期间测量血清尿酸浓度。最常受累的关节为肩部、膝盖和手指，症状和体征总体上既不严重也不持久。在所有3组中，大多数患者的关节症状和体征在8周内有所改善，但阿司匹林组和安慰剂组中症状改善的患者比例高于别嘌醇组，阿司匹林组的改善最为迅速。仅在阿司匹林组中，治疗期间的平均血清尿酸浓度低于治疗前，且这种效应与每千克体重的剂量相关。得出的结论是，关节痛通常为自限性，阿司匹林有轻微有益作用，在所研究剂量下别嘌醇可能有轻微有害作用，但值得研究更大剂量的别嘌醇，因为所研究的剂量未影响血清尿酸浓度。
