Jenner P J, Ellard G A, Allan W G, Singh D, Girling D J, Nunn A J
Tubercle. 1981 Sep;62(3):175-9. doi: 10.1016/0041-3879(81)90003-9.
The serum uric acid concentrations of patients being treated in Hong Kong and Singapore with a daily regimen consisting of streptomycin, isoniazid, rifampicin and pyrazinamide or a control regimen of daily streptomycin, p-amino-salicylic acid (PAS) and isoniazid were determined by the phosphotungstate method. Arthralgia and elevated serum uric acid levels were encountered only during the period that patients were being treated with pyrazinamide. Although daily treatment with pyrazinamide increased serum uric acid concentrations approximately 2.5-fold, the concentrations of the 6 patients who developed arthralgia were closely similar to those of matched controls without arthralgia. This fails to confirm a previous suggestion that patients with arthralgia might have higher values. Rifampicin appeared not to influence the hyperuricaemic effect of pyrazinamide.
采用磷钨酸盐法测定了在香港和新加坡接受由链霉素、异烟肼、利福平及吡嗪酰胺组成的每日治疗方案或由链霉素、对氨基水杨酸（PAS）及异烟肼组成的对照方案治疗的患者的血清尿酸浓度。仅在患者接受吡嗪酰胺治疗期间出现关节痛和血清尿酸水平升高。尽管每日使用吡嗪酰胺治疗使血清尿酸浓度增加约2.5倍，但6例出现关节痛的患者的浓度与未出现关节痛的匹配对照者的浓度非常相似。这未能证实之前关于关节痛患者可能有更高值的推测。利福平似乎不影响吡嗪酰胺的高尿酸血症效应。
