Department of Integrated Traditional Chinese and Western Medicine, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Jiefang Avenue No.1277, 430000, Wuhan, China.
Department of Respiratory and Critical Care Medicine, Center for Biomedical Research, NHC Key Laboratory of Respiratory Diseases, Tongji Hospital, Tongji Medical College, Huazhong University of Sciences and Technology, Jiefang Avenue No.1095, 430000, Wuhan, China.
J Leukoc Biol. 2023 Nov 24;114(6):518-531. doi: 10.1093/jleuko/qiad117.
Lysosomal compartments undergo extensive remodeling during dendritic cell (DC) activation to meet the dynamic functional requirements of DCs. Instead of being regarded as stationary and digestive organelles, recent studies have increasingly appreciated the versatile roles of lysosomes in regulating key aspects of DC biology. Lysosomes actively control DC motility by linking calcium efflux to the actomyosin contraction, while enhanced DC lysosomal membrane permeability contributes to the inflammasome activation. Besides, lysosomes provide a platform for the transduction of innate immune signaling and the intricate host-pathogen interplay. Lysosomes and lysosome-associated structures are also critically engaged in antigen presentation and cross-presentation processes, which are pivotal for the induction of antigen-specific adaptive immune response. Through the current review, we emphasize that lysosome targeting strategies serve as vital DC-based immunotherapies in fighting against tumor, infectious diseases, and autoinflammatory disorders.
溶酶体在树突状细胞 (DC) 激活过程中经历广泛的重塑，以满足 DC 动态功能的要求。溶酶体不再被视为静止和消化细胞器，最近的研究越来越重视溶酶体在调节 DC 生物学关键方面的多种作用。溶酶体通过将钙外排与肌动球蛋白收缩相连接，从而积极控制 DC 的运动，而增强的 DC 溶酶体膜通透性有助于炎性体的激活。此外，溶酶体为先天免疫信号转导和复杂的宿主-病原体相互作用提供了一个平台。溶酶体和溶酶体相关结构也在抗原呈递和交叉呈递过程中发挥关键作用，这对于诱导抗原特异性适应性免疫反应至关重要。通过本次综述，我们强调，溶酶体靶向策略作为基于 DC 的免疫疗法，在对抗肿瘤、传染病和自身炎症性疾病方面具有重要作用。
