抗精神病药物和抗抑郁药物对与hERG通道功能障碍相关的长QT综合征诱发的影响：一项系统评价。
Impact of antipsychotics and antidepressants drugs on long QT syndrome induction related to hERG channel dysfunction: A systematic review.
作者信息
Nemati Marzieh, Hosseinzadeh Zahra, Nemati Fatemeh, Ebrahimi Bahareh
机构信息
Endocrinology and Metabolism Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
School of Dentistry, Shiraz University of Medical Science, Shiraz, Iran.
出版信息
Biochem Biophys Res Commun. 2023 Nov 12;681:90-96. doi: 10.1016/j.bbrc.2023.09.043. Epub 2023 Sep 23.
PURPOSE
QT prolongation is one of the main unwanted cardiac effects caused by drugs, such as anti-psychotics and anti-depressants, inducing mainly via hERG channel dysfunction. The precise and underlying mechanism of adverse effects on hERG channel are still indecisive, but these effects limit their use in patients with cardiac risk factors. The aim of this review was studying mechanism of Long-term QT syndrome induction via hERG channel dysfunction by these Drugs.
METHOD
Search was performed in PubMed, and Scopus. All human, animals, and cell lines studies, English and full text publications were included. Among 1280 papers, 23 studies were eligible for more assessments. Quality of studies cheeked by two researchers independently.
KEY FINDING
most of studies were done on anti-psychotic drugs, especially typical class. Most used investigated method to long-term QT induction was patch clamp.
SIGNIFICANCE
results suggests in susceptible cases with heart risk factors, these drugs should be taken with caution and monitored.
目的
QT间期延长是抗精神病药和抗抑郁药等药物引起的主要不良心脏效应之一，主要通过hERG通道功能障碍诱发。对hERG通道产生不良反应的确切潜在机制仍不明确，但这些效应限制了它们在有心脏危险因素患者中的使用。本综述的目的是研究这些药物通过hERG通道功能障碍诱发长期QT综合征的机制。
方法
在PubMed和Scopus中进行检索。纳入所有人类、动物和细胞系研究，英文及全文出版物。在1280篇论文中，有23项研究符合进一步评估的条件。研究质量由两名研究人员独立检查。
主要发现
大多数研究针对抗精神病药物，尤其是典型类别。最常用的诱发长期QT的研究方法是膜片钳。
意义
结果表明，在有心脏危险因素的易感病例中，应谨慎使用这些药物并进行监测。
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