Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Department of Translational Molecular Pathology, The University of Texas MD Anderson Cancer Center, Houston, TX, USA; UTHealth Houston Graduate School of Biomedical Sciences (GSBS), The University of Texas MD Anderson Cancer Center, Houston, TX, USA.
Cancer Cell. 2023 Nov 13;41(11):1846-1848. doi: 10.1016/j.ccell.2023.09.002. Epub 2023 Sep 28.
Increasing evidence suggests that tumors harbor diverse microbiomes, adding complexity to the tumor microenvironment. In this issue of Cancer Cell, Liu et al. highlight the role of the intratumor mycobiome, specifically Aspergillus sydowii, in promoting lung adenocarcinoma progression. A. sydowii enhances the recruitment and activation of myeloid-derived suppressor cells via IL-1β signaling driven by the β-glucan-mediated Dectin-1/CARD9 pathway.
越来越多的证据表明，肿瘤内部栖息着多样化的微生物群落，这为肿瘤微环境增添了复杂性。在本期《癌细胞》杂志中，刘等人强调了肿瘤内真菌群落（特别是黄曲霉）在促进肺腺癌进展方面的作用。黄曲霉通过 β-葡聚糖介导的 Dectin-1/CARD9 通路驱动的 IL-1β 信号，增强了髓系来源的抑制细胞的募集和激活。
