Division of Nephrology, Children's Hospital Los Angeles, Los Angeles, California, USA.
Division of Nephrology, Children's Hospital of Philadelphia, Philadelphia, Pennsylvania, USA.
Pediatr Blood Cancer. 2023 Dec;70(12):e30696. doi: 10.1002/pbc.30696. Epub 2023 Sep 30.
Children with acute leukemia are at increased risk of kidney injury. Using electronic health record data from three centers between 2010 and 2018, this study retrospectively described acute kidney injury (AKI) and chronic kidney disease (CKD) prevalence in children with acute lymphoblastic or myeloid leukemia (ALL, AML) using Common Terminology Criteria for Adverse Events (CTCAE) and Kidney Disease Improving Global Outcomes (KDIGO) definitions. AKI during therapy was 25% (ALL) and 32% (AML) using CTCAE, versus 84% (ALL) and 74% (AML) using KDIGO. CKD prevalence was low and Grade 1/Stage 2. Further investigation is needed to optimally define kidney injury in acute leukemia.
患有急性白血病的儿童肾脏损伤风险增加。本研究使用 2010 年至 2018 年三个中心的电子健康记录数据，根据不良事件通用术语标准（CTCAE）和肾脏疾病改善全球结局（KDIGO）定义，回顾性描述了患有急性淋巴细胞白血病或急性髓细胞白血病（ALL、AML）儿童的急性肾损伤（AKI）和慢性肾脏病（CKD）的患病率。使用 CTCAE 时，ALL 组和 AML 组的 AKI 发生率分别为 25%和 32%，而使用 KDIGO 时，ALL 组和 AML 组的 AKI 发生率分别为 84%和 74%。CKD 的患病率较低，为 1 级/2 期。需要进一步的研究来最佳定义急性白血病中的肾脏损伤。
