Department of Biomedical Sciences, Advanced Medical and Dental Institute, Universiti Sains Malaysia, Kepala Batas, Pulau Pinang, 13200, Malaysia.
Department of Medical Laboratory Sciences, University of Health and Allied Sciences, PMB 31, Ho, Ghana.
Mol Biol Rep. 2023 Nov;50(11):9575-9585. doi: 10.1007/s11033-023-08810-w. Epub 2023 Sep 30.
Colorectal cancer (CRC) is a serious global health concern, with a high incidence and mortality rate. Although there have been advancements in the early detection and treatment of CRC, therapy resistance is common. MicroRNAs (miRNAs), a type of small non-coding RNA that regulates gene expression, are key players in the initiation and progression of CRC. Recently, there has been growing attention to the complex interplay of miRNAs in cancer development. miRNAs are powerful RNA molecules that regulate gene expression and have been implicated in various physiological and pathological processes, including carcinogenesis. By identifying current challenges and limitations of treatment strategies and suggesting future research directions, this review aims to contribute to ongoing efforts to enhance CRC diagnosis and treatment. It also provides a comprehensive overview of the role miRNAs play in CRC carcinogenesis and explores the potential of miRNA-based therapies as a treatment option. Importantly, this review highlights the exciting potential of targeted modulation of miRNA function as a therapeutic approach for CRC.
结直肠癌（CRC）是一个严重的全球健康问题，具有较高的发病率和死亡率。尽管在 CRC 的早期检测和治疗方面已经取得了进展，但治疗耐药性仍然很常见。微小 RNA（miRNA）是一种调节基因表达的小型非编码 RNA，是 CRC 发生和发展的关键因素。最近，miRNA 在癌症发展中的复杂相互作用引起了越来越多的关注。miRNA 是一种强大的 RNA 分子，可调节基因表达，并与各种生理和病理过程有关，包括致癌作用。通过确定当前治疗策略的挑战和局限性，并提出未来的研究方向，本综述旨在为提高 CRC 的诊断和治疗水平做出贡献。它还全面概述了 miRNA 在 CRC 癌变中的作用，并探讨了 miRNA 为基础的治疗作为一种治疗选择的潜力。重要的是，本综述强调了靶向调节 miRNA 功能作为 CRC 治疗方法的令人兴奋的潜力。
