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肿瘤相关巨噬细胞表型在结直肠癌中的预后价值和预测生物标志物。

Prognostic value and predictive biomarkers of phenotypes of tumour-associated macrophages in colorectal cancer.

机构信息

Jiangsu Key Laboratory of Integrated Traditional Chinese and Western Medicine for Prevention and Treatment of Senile Diseases, Medical College of Yangzhou University, Yangzhou, China.

Department of Traditional Chinese Medicine, Affiliated Hospital of Yangzhou University, Yangzhou, China.

出版信息

Scand J Immunol. 2022 Apr;95(4):e13137. doi: 10.1111/sji.13137. Epub 2022 Jan 10.

DOI:10.1111/sji.13137
PMID:34964155
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC9286461/
Abstract

BACKGROUND

The roles of different subtypes of tumour-associated macrophages (TAMs) in predicting the prognosis of colorectal cancer (CRC) remain controversial. In this study, different subtypes of TAMs were investigated as prognostic and predictive biomarkers for CRC.

METHODS

Expressions of CD68, CD86 and CD163 were investigated by immunohistochemistry (IHC) and immunofluorescence (IF), and the correlation between the expression of CD86 and CD163 was calculated in colorectal cancer tissues from 64 CRC patients.

RESULTS

The results showed that high expressions of CD86 and CD68 CD86 TAMs as well as low expression of CD163 and CD68 CD163 TAMs were significantly associated with favourable overall survival (OS). The level of CD86 protein expression showed a negative correlation with CD163 protein expression. In addition, CD86 protein expression remarkably negatively correlated with tumour differentiation and tumour node metastasis (TNM) stage, while CD163 protein expression significantly positively correlated with tumour differentiation and tumour size. As an independent risk factor, high expression of CD86 TAMs had prominently favourable prognostic efficacy, while high expression of CD68 CD163 TAMs had significantly poor prognostic efficacy.

CONCLUSIONS

These results indicate that CD86 and CD68 CD163 TAMs as prognostic and predictive biomarkers for CRC.

摘要

背景

肿瘤相关巨噬细胞（TAMs）的不同亚型在预测结直肠癌（CRC）预后中的作用仍存在争议。本研究探讨了不同亚型的 TAMs 作为 CRC 的预后和预测生物标志物的作用。

方法

采用免疫组织化学（IHC）和免疫荧光（IF）检测 64 例 CRC 患者肿瘤组织中 CD68、CD86 和 CD163 的表达，并计算 CD86 和 CD163 的表达相关性。

结果

结果表明，CD86 和 CD68 CD86 TAMs 的高表达以及 CD163 和 CD68 CD163 TAMs 的低表达与良好的总生存期（OS）显著相关。CD86 蛋白表达水平与 CD163 蛋白表达水平呈负相关。此外，CD86 蛋白表达与肿瘤分化和肿瘤淋巴结转移（TNM）分期显著负相关，而 CD163 蛋白表达与肿瘤分化和肿瘤大小显著正相关。作为独立的危险因素，CD86 TAMs 的高表达具有显著的预后疗效，而 CD68 CD163 TAMs 的高表达则具有显著的预后不良疗效。

结论

这些结果表明 CD86 和 CD68 CD163 TAMs 可作为 CRC 的预后和预测生物标志物。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/26c49560e71c/SJI-95-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/554559215502/SJI-95-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/176282b67662/SJI-95-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/117f16cff718/SJI-95-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/26c49560e71c/SJI-95-0-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/554559215502/SJI-95-0-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/176282b67662/SJI-95-0-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/117f16cff718/SJI-95-0-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/abae/9286461/26c49560e71c/SJI-95-0-g004.jpg

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