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年度重大进展:胰腺癌。

Top advances of the year: Pancreatic cancer.

机构信息

Division of Surgical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

Department of Hematology and Medical Oncology, Winship Cancer Institute, Emory University, Atlanta, GA, USA.

出版信息

Cancer. 2023 Dec 15;129(24):3843-3851. doi: 10.1002/cncr.35031. Epub 2023 Sep 30.

Abstract

This commentary highlights the key recent advances made in the field of pancreatic cancer. Although there has yet to be a major breakthrough in clinical care for the majority of patients, significant strides have been made in understanding the complex biology of this malignancy and identifying new therapeutic targets.

摘要

本述评重点介绍了胰腺癌领域的最新重要进展。尽管大多数患者的临床治疗尚未取得重大突破,但在深入了解这种恶性肿瘤的复杂生物学特性以及确定新的治疗靶点方面已经取得了显著进展。

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本文引用的文献

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Uridine-derived ribose fuels glucose-restricted pancreatic cancer.尿苷衍生的核糖为葡萄糖限制的胰腺癌供能。
Nature. 2023 Jun;618(7963):151-158. doi: 10.1038/s41586-023-06073-w. Epub 2023 May 17.
6
Adagrasib in Advanced Solid Tumors Harboring a Mutation.在携带突变的晚期实体瘤中应用阿达格拉西布
J Clin Oncol. 2023 Sep 1;41(25):4097-4106. doi: 10.1200/JCO.23.00434. Epub 2023 Apr 26.
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Pancreatic cancer: Advances and challenges.胰腺癌:进展与挑战。
Cell. 2023 Apr 13;186(8):1729-1754. doi: 10.1016/j.cell.2023.02.014.

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