Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen Ø 2100, Denmark.
Department of Pharmacy, Faculty of Health and Medical Sciences, University of Copenhagen, Universitetsparken 2, Copenhagen Ø 2100, Denmark; Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC, Australia.
J Control Release. 2023 Nov;363:536-549. doi: 10.1016/j.jconrel.2023.09.049. Epub 2023 Oct 9.
The formation of a biomolecular corona on exogenous particles in plasma is well studied and is known to dictate the biodistribution and cellular interactions of nanomedicine formulations. In contrast, while the oral route is the most favorable administration method for pharmaceuticals, little is known about the formation and composition of the corona formed by biomolecules on particles within the gastrointestinal tract. This work reviews the current literature understanding of (1) the formation of drug particles after oral administration, (2) the formation of a biomolecular corona within the gastrointestinal tract ("the gastrointestinal corona"), and (3) the possible implications of the formation of a gastrointestinal corona on the interactions of drug particles with their biological environment. In doing so, this work aims to establish the significance of the formation of a gastrointestinal corona in oral drug delivery to ultimately arrive at new avenues to control the behavior of orally administered pharmaceuticals.
生物分子在血浆中外源颗粒上形成的生物分子冠层已得到充分研究，并且已知其决定了纳米药物制剂的生物分布和细胞相互作用。相比之下，虽然口服途径是药物最理想的给药方法，但对于胃肠道内颗粒上形成的生物分子冠层的形成和组成知之甚少。这项工作综述了目前关于（1）口服给药后药物颗粒的形成、（2）胃肠道内生物分子冠层的形成（“胃肠道冠层”）以及（3）胃肠道冠层形成对药物颗粒与生物环境相互作用的可能影响的文献理解。这样做的目的是确定在口服药物递送中形成胃肠道冠层的重要性，最终找到控制口服药物行为的新途径。
