More N S, Rao N A, Preuss H G
Ann Clin Lab Sci. 1986 Sep-Oct;16(5):419-26.
Retinal capillary basement membrane damage was demonstrated over a relatively short time period (two to three months) by feeding a diet containing high amounts of sucrose to spontaneously hypertensive rats (SHR) and their normotensive controls, Wistar Kyoto rats (WKY). Similar changes did not occur in SHR and WKY on a high starch diet. The early damage to the capillaries consisted of thickening of capillary basement membranes, loss of homogeneity, and inclusions containing debris. Previous studies on sucrose-induced eye lesions have reported chronic pathological changes only after prolonged periods of heavy sucrose ingestion, usually exceeding one year. Accordingly, the temporally foreshortened experimental pathogenesis offered by the SHR/WKY model allowed us to examine early changes in sucrose-induced vascular eye lesions.
通过给自发性高血压大鼠（SHR）及其血压正常的对照Wistar Kyoto大鼠（WKY）喂食含有大量蔗糖的饮食，在相对较短的时间段（两到三个月）内证实了视网膜毛细血管基底膜损伤。高淀粉饮食的SHR和WKY未出现类似变化。毛细血管的早期损伤包括毛细血管基底膜增厚、均质性丧失以及含有碎片的内含物。先前关于蔗糖诱导眼部病变的研究仅报道了长期大量摄入蔗糖（通常超过一年）后的慢性病理变化。因此，SHR/WKY模型提供的时间缩短的实验发病机制使我们能够研究蔗糖诱导的血管性眼部病变的早期变化。
