Rateau J G, Brouillard M, Morgant G, Aymard P
Ann Gastroenterol Hepatol (Paris). 1986 Oct;22(5):289-96.
Cholestyramine is a non-absorbable anion exchange resin. Cholestyramine treatment of new born's infectious diarrhea has been shown to be effective. Cholera toxin induces, in the adult rabbit ileal loop, histological, water electrolytes and enzymatic modifications similar to that observed in patients with acute infectious diarrhea. Using this experimental model, we try to exhibit the reduction of the pathologic secretory action of the toxin on intestinal loop, after contact with the resin. A prolonged contact of the cholera toxin with the resin does not abolish completely the activation of adenyl-cyclase induced by the toxin alone. However significant reduction of goblet cell degranulation, and of the secretory effect allowed to reduce the loss of water and electrolytes.
消胆胺是一种不可吸收的阴离子交换树脂。已证明消胆胺治疗新生儿感染性腹泻有效。霍乱毒素在成年兔回肠袢中可诱导出与急性感染性腹泻患者相似的组织学、水电解质及酶学改变。利用该实验模型，我们试图展示毒素与树脂接触后，其对肠袢病理性分泌作用的降低情况。霍乱毒素与树脂的长时间接触并不能完全消除毒素单独诱导的腺苷酸环化酶激活。然而，杯状细胞脱颗粒及分泌效应的显著降低使得水电解质丢失减少。
