Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Preventative Gynecology Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran.
Explore (NY). 2024 May-Jun;20(3):334-339. doi: 10.1016/j.explore.2023.09.004. Epub 2023 Sep 19.
The present study aimed to determine the efficacy of EstroG-100 herbal extract on hot flashes in postmenopausal women.
This randomized, double-blind, placebo-controlled trial was performed on postmenopausal women recruited from two university hospitals complaining of hot flashes. The intervention group received two extract capsules (daily for 12 weeks), and the control group received two placebo capsules (daily for 12 weeks). Finally, the frequency and severity of hot flashes (F&S) were subjectively reported and compared weekly during the treatment for 12 weeks.
Out of 120 randomized participants, 35 entered the final analysis for each group. In the third week, participants of the control group significantly reported more moderate hot flashes than other group (MD=1.00, P = 0.004). However, in terms of mild (MD=0.74, P = 0.057) and severe (MD=0.60, P = 0.064) hot flashes, the groups did not differ. In the sixth week, mild (MD=1.51, P<0.001), moderate (MD=1.54, P<0.001), and severe (MD=1.22, P<0.001) hot flashes were significantly reported more in the control group compared with another group.
The present study revealed that EstroG-100 herbal extract could improve hot flashes in postmenopausal women.
本研究旨在确定 EstroG-100 草药提取物对绝经后妇女热潮红的疗效。
这项随机、双盲、安慰剂对照试验招募了两所大学医院因热潮红而抱怨的绝经后妇女。干预组每天服用两种提取物胶囊（持续 12 周），对照组每天服用两种安慰剂胶囊（持续 12 周）。最后，在 12 周的治疗期间每周主观报告和比较热潮红的频率和严重程度（F&S）。
在 120 名随机参与者中，35 名进入了每个组的最终分析。在第 3 周，对照组参与者明显报告了更多的中度热潮红（MD=1.00，P=0.004）。然而，在轻度（MD=0.74，P=0.057）和重度（MD=0.60，P=0.064）热潮红方面，两组没有差异。在第 6 周，对照组明显报告了更多的轻度（MD=1.51，P<0.001）、中度（MD=1.54，P<0.001）和重度（MD=1.22，P<0.001）热潮红。
本研究表明，EstroG-100 草药提取物可以改善绝经后妇女的热潮红。
