Life Sciences Center, Vilnius University, Vilnius, LT-10257, Lithuania.
Florey Institute of Neuroscience and Mental Health, Melbourne, VIC 3010, Australia; Florey Department of Neuroscience and Mental Health, University of Melbourne, Melbourne, VIC 3010, Australia.
Trends Neurosci. 2023 Dec;46(12):1018-1024. doi: 10.1016/j.tins.2023.09.001. Epub 2023 Sep 30.
Planning and anticipating motor actions enables movements to be quickly and accurately executed. However, if anticipation is not properly controlled, it can lead to premature impulsive actions. Impulsive behavior is defined as actions that are poorly conceived and are often risky and inappropriate. Historically, impulsive behavior was thought to be primarily controlled by the frontal cortex and basal ganglia. More recently, two additional brain regions, the ventromedial (VM) thalamus and the anterior lateral motor cortex (ALM), have been shown to have an important role in mice. Here, we explore this newly discovered role of the thalamocortical pathway and suggest cellular mechanisms that may be involved in driving the cortical activity that contributes to impulsive behavior.
计划和预期运动动作可以使动作快速准确地执行。然而，如果预期控制不当，可能会导致冲动的过早行为。冲动行为的定义是行动考虑不周，往往是有风险和不适当的。从历史上看，冲动行为被认为主要由额叶皮层和基底神经节控制。最近，两个额外的大脑区域，腹内侧（VM）丘脑和前外侧运动皮层（ALM），已被证明在小鼠中具有重要作用。在这里，我们探讨了这条新发现的丘脑皮质通路的作用，并提出了可能参与驱动皮质活动的细胞机制，这些皮质活动有助于冲动行为。
