FGF23 信号的结构不对称性。
Structural asymmetry in FGF23 signaling.
机构信息
UT/ORNL Center for Molecular Biophysics, Oak Ridge National Laboratory, Oak Ridge, TN 37831, USA; Department of Biochemistry and Cellular and Molecular Biology, University of Tennessee, Knoxville, TN 37996, USA.
Department of Medicine, College of Medicine, University of Tennessee Health Science Center, Memphis, TN 38163, USA.
出版信息
Trends Pharmacol Sci. 2023 Dec;44(12):862-864. doi: 10.1016/j.tips.2023.09.005. Epub 2023 Sep 29.
Abstract
Chen et al. have derived cryogenic electron microscopy (cryo-EM) structures of signaling complexes of the endocrine hormone fibroblast growth factor 23 (FGF23) with fibroblast growth factor receptor (FGFR), α-Klotho, and heparin sulfate. These structures are asymmetric, leading to questions concerning in vivo function, and will facilitate structure-based drug design to modulate FGF23 signaling.
摘要
陈等人已经获得了内分泌激素成纤维细胞生长因子 23（FGF23）与成纤维细胞生长因子受体（FGFR）、α-Klotho 和硫酸肝素结合的信号复合物的低温电子显微镜（cryo-EM）结构。这些结构是不对称的，这引发了关于体内功能的问题，并将促进基于结构的药物设计以调节 FGF23 信号。
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