Anufrieva R G, Baru R V, Lapchinskaia A V
Antibiot Med Biotekhnol. 1986 Sep;31(9):695-8.
The embryotoxic and teratogenic effects of cefalexin were studied on Wistar albino rats subjected to inhalations of the antibiotic within the whole gravidity term. It was shown that in a concentration of 1.29 mg/m3 cefalexin did not increase the rate of fetus intrauterine death, had no unfavourable effect on the fetus and placenta development and did not induce anomalies in development of the fetus internal organs. The frequency of sensitization in the gravid and nongravid animals was the same. No signs of sensitization were detected in the litter of the rats treated with cefalexin inhalations.
在整个妊娠期对接受抗生素吸入的Wistar白化大鼠研究了头孢氨苄的胚胎毒性和致畸作用。结果表明,在浓度为1.29 mg/m³时,头孢氨苄不会增加胎儿宫内死亡率,对胎儿和胎盘发育没有不利影响,也不会诱发胎儿内脏发育异常。妊娠和非妊娠动物的致敏频率相同。在接受头孢氨苄吸入治疗的大鼠的幼崽中未检测到致敏迹象。