预测痴呆症各阶段、住院和死亡的逗留时间。
Predicting sojourn times across dementia disease stages, institutionalization, and mortality.
机构信息
Division of Neurogeriatrics, Department of Neurobiology, Care Sciences and Society, Karolinska Institutet, Stockholm, Sweden.
Univ, Bordeaux, Inserm U1219, PHARes team, Institut de Santé Publique, d'Epidémiologie et de Développement (ISPED), Bordeaux, France.
出版信息
Alzheimers Dement. 2024 Feb;20(2):809-818. doi: 10.1002/alz.13488. Epub 2023 Oct 1.
INTRODUCTION
Inferring the timeline from mild cognitive impairment (MCI) to severe dementia is pivotal for patients, clinicians, and researchers. Literature is sparse and often contains few patients. We aim to determine the time spent in MCI, mild-, moderate-, severe dementia, and institutionalization until death.
METHODS
Multistate modeling with Cox regression was used to obtain the sojourn time. Covariates were age at baseline, sex, amyloid status, and Alzheimer's disease (AD) or other dementia diagnosis. The sample included a register (SveDem) and memory clinics (Amsterdam Dementia Cohort and Memento).
RESULTS
Using 80,543 patients, the sojourn time from clinically identified MCI to death across all patient groups ranged from 6.20 (95% confidence interval [CI]: 5.57-6.98) to 10.08 (8.94-12.18) years.
DISCUSSION
Generally, sojourn time was inversely associated with older age at baseline, males, and AD diagnosis. The results provide key estimates for researchers and clinicians to estimate prognosis.
简介
从轻度认知障碍（MCI）推断到严重痴呆的时间线对患者、临床医生和研究人员至关重要。文献很少，且通常包含的患者人数较少。我们旨在确定从 MCI 到死亡的时间，包括轻度、中度、重度痴呆和住院时间。
方法
使用多状态建模和 Cox 回归来获得逗留时间。协变量包括基线时的年龄、性别、淀粉样蛋白状态以及阿尔茨海默病（AD）或其他痴呆诊断。样本包括一个登记处（SveDem）和记忆诊所（阿姆斯特丹痴呆队列和 Memento）。
结果
使用 80543 名患者，所有患者群体从临床诊断的 MCI 到死亡的逗留时间范围从 6.20（95%置信区间 [CI]：5.57-6.98）到 10.08（8.94-12.18）年。
讨论
一般来说，逗留时间与基线时的年龄较大、男性和 AD 诊断呈负相关。这些结果为研究人员和临床医生提供了关键的预后估计。
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