Department of Rehabilitation Medicine, Faculty of Medicine, Chiang Mai University, Chiang Mai, 50200, Thailand.
J Med Case Rep. 2023 Oct 2;17(1):415. doi: 10.1186/s13256-023-04152-0.
Single-time non-invasive brain stimulation was carried out using the two-technique approach on a patient suffering from treatment-resistant depression. Five treatment sessions given at weekly intervals resulted in a significant improvement in the Patient Health Questionnaire-9 score for up to 6 weeks. The findings of this study could pave the way for a more efficient less resource-intensive time- and budget-saving technique of employing non-invasive brain stimulation for patients with treatment-resistant depression by minimizing the number of stimulation sessions.
A 67-year-old married non-Latino white American woman suffering from treatment-resistant depression received intermittent tetraburst stimulation in combination with transcranial direct current stimulation weekly for 5 consecutive weeks. Diagnostic transcranial magnetic stimulation showed an observable electrophysiological change. The patient reported a drastic improvement in Patient Health Questionnaire-9 score up until 6-week follow-up and expressed satisfaction with the treatment.
This case study suggests that a streamlined protocol for using non-invasive brain stimulation could prove more effective for patients and healthcare providers in terms of safety in comparison to the present guidelines.
对一名患有难治性抑郁症的患者，采用双技术方法进行单次非侵入性脑刺激。每周进行 5 次治疗，患者健康问卷-9 评分在 6 周内显著改善。本研究的结果可能为通过减少刺激次数，为患有难治性抑郁症的患者提供一种更高效、资源消耗更少、省时省钱的非侵入性脑刺激技术铺平道路。
一名 67 岁的已婚非拉丁裔美国白人妇女患有难治性抑郁症，接受了间歇性四脉冲刺激联合每周经颅直流电刺激连续 5 周。诊断性经颅磁刺激显示出可观察到的电生理变化。患者报告说，在 6 周随访时，患者健康问卷-9 评分有明显改善，并对治疗表示满意。
与目前的指南相比，这种简化的非侵入性脑刺激使用方案可能在安全性方面为患者和医疗服务提供者提供更有效的治疗。
