National Clinical Research Centre for Chinese Medicine Cardiology, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Second Department of Geriatrics, Xiyuan Hospital of China Academy of Chinese Medical Sciences, Beijing, China.
Curr Vasc Pharmacol. 2023;21(5):316-345. doi: 10.2174/0115701611249727230920042944.
To investigate the current status and development trend of research on exosomes in cardiovascular disease (CVD) using bibliometric analysis and to elucidate trending research topics.
Research articles on exosomes in CVD published up to April 2022 were retrieved from the Web of Science database. Data were organized using Microsoft Office Excel 2019. CiteSpace 6.1 and VOSviewer 1.6.18 were used for bibliometric analysis and result visualization.
Overall, 256 original research publications containing 190 fundamental research publications and 66 clinical research publications were included. "Extracellular vesicle" was the most frequent research keyword, followed by "microrna," "apoptosis," and "angiogenesis." Most publications were from China (187, 73.05%), followed by the United States (57, 22.27%), the United Kingdom (7, 2.73%), and Japan (7, 2.73%). A systematic review of the publications revealed that myocardial infarction and stroke were the most popular topics and that exosomes and their contents, such as microRNAs (miRNAs), play positive roles in neuroprotection, inhibition of autophagy and apoptosis, promotion of angiogenesis, and protection of cardiomyocytes.
Research on exosomes in CVD has attracted considerable attention, with China having the most published studies. Fundamental research has focused on CVD pathogenesis; exosomes regulate the progression of CVD through biological processes, such as the inflammatory response, autophagy, and apoptosis. Clinical research has focused on biomarkers for CVD; studies on using miRNAs in exosomes as disease markers for diagnosis could become a future trend.
使用文献计量学分析探讨心血管疾病（CVD）中外泌体的研究现状和发展趋势，并阐明热门研究主题。
从 Web of Science 数据库中检索截至 2022 年 4 月发表的关于 CVD 中外泌体的研究文章。使用 Microsoft Office Excel 2019 对数据进行组织。使用 CiteSpace 6.1 和 VOSviewer 1.6.18 进行文献计量学分析和结果可视化。
共纳入 256 篇原创研究出版物，其中 190 篇为基础研究出版物，66 篇为临床研究出版物。“细胞外囊泡”是最常出现的研究关键词，其次是“miRNA”、“细胞凋亡”和“血管生成”。大多数出版物来自中国（187 篇，73.05%），其次是美国（57 篇，22.27%）、英国（7 篇，2.73%）和日本（7 篇，2.73%）。对出版物进行系统回顾后发现，心肌梗死和中风是最受欢迎的主题，外泌体及其内容（如 microRNAs（miRNAs））在神经保护、抑制自噬和细胞凋亡、促进血管生成以及保护心肌细胞方面发挥着积极作用。
CVD 中外泌体的研究受到了广泛关注，中国发表的研究数量最多。基础研究集中在 CVD 发病机制上；外泌体通过炎症反应、自噬和细胞凋亡等生物学过程调节 CVD 的进展。临床研究集中在 CVD 的生物标志物上；关于将外泌体中的 miRNAs 用作疾病标志物进行诊断的研究可能成为未来的趋势。
