Kim Kyu Min, Shin Eun Jin, Yang Ji Hye, Ki Sung Hwan
Department of Biomedical Science, College of Natural Science, Chosun University, Gwangju, 61452 Republic of Korea.
College of Korean Medicine, Dongshin University, Naju, Jeollanam-Do 58245 Republic of Korea.
Toxicol Res. 2023 Jun 19;39(4):549-564. doi: 10.1007/s43188-023-00193-1. eCollection 2023 Oct.
Bioactive sphingolipids and enzymes that metabolize sphingolipid-related substances have been considered as critical messengers in various signaling pathways. One such enzyme is the crucial lipid kinase, sphingosine kinase (SphK), which mediates the conversion of sphingosine to the potent signaling substance, sphingosine-1-phosphate. Several studies have demonstrated that SphK metabolism is strictly regulated to maintain the homeostatic balance of cells. Here, we summarize the role of SphK in the course of liver disease and illustrate its effects on both physiological and pathological conditions of the liver. SphK has been implicated in a variety of liver diseases, such as steatosis, liver fibrosis, hepatocellular carcinoma, and hepatic failure. This study may advance the understanding of the cellular and molecular foundations of liver disease and establish therapeutic approaches via SphK modulation.
生物活性鞘脂以及代谢鞘脂相关物质的酶被认为是各种信号通路中的关键信使。其中一种这样的酶是关键的脂质激酶——鞘氨醇激酶（SphK），它介导鞘氨醇转化为强效信号物质鞘氨醇-1-磷酸。多项研究表明，SphK代谢受到严格调控以维持细胞的稳态平衡。在此，我们总结SphK在肝病进程中的作用，并阐述其对肝脏生理和病理状况的影响。SphK与多种肝病有关，如脂肪变性、肝纤维化、肝细胞癌和肝衰竭。本研究可能会加深对肝病细胞和分子基础的理解，并通过调节SphK建立治疗方法。
