Arulmozhi Sivan, Sasikumar Gopalakrishnan, Subramani Annadurai, Mohammed Mustafa K A, Ali Syed J Askar, Ponnusamy Sasikumar, Jabir Majid S, Elgorban Abdallah M, Zhang Wanli, Natarajan Hema
Post-Graduate and Research Department of Chemistry, the New College (Autonomous), Chennai 600014, India.
Department of Chemistry, St. Joseph's College of Engineering, OMR, Chennai 600 119, India.
ACS Omega. 2023 Sep 14;8(38):34458-34470. doi: 10.1021/acsomega.3c02860. eCollection 2023 Sep 26.
Some new transition metal complexes were prepared by reacting metal(II) salts with Schiff base azines, which were prepared via condensation of 5-(diethylamino) salicylaldehyde and hydrazine with pyrrole-2-carbaldehyde. Their structures were confirmed based on CHN, UV-visible, FT-IR, and EPR measurements. The complexes were also assessed for their antibacterial, antioxidant, and anticancer properties. Some of these chemicals were said to be extraordinarily effective in this respect. The antibacterial activities of the complexes in vitro demonstrated their potential, although the [Cu(L)(bpy] complex was suggested to exhibit moderate activity against pathogens compared to all other in this series. The cytotoxic activity of the prepared analogues showed better cell viability compared with standard cisplatin. Moreover, there is a good agreement between the experimental and theoretical findings from docking and theoretical investigations done using DFT at the B3LYP level.
通过金属（II）盐与席夫碱嗪反应制备了一些新型过渡金属配合物，席夫碱嗪是由5-（二乙氨基）水杨醛、肼与吡咯-2-甲醛缩合制备而成。基于CHN、紫外可见、傅里叶变换红外光谱和电子顺磁共振测量确定了它们的结构。还评估了这些配合物的抗菌、抗氧化和抗癌性能。据说其中一些化合物在这方面非常有效。配合物的体外抗菌活性证明了它们的潜力，不过与该系列中的所有其他配合物相比，[Cu（L）（bpy）]配合物对病原体的活性被认为是中等的。所制备类似物的细胞毒性活性与标准顺铂相比显示出更好的细胞活力。此外，在使用B3LYP水平的密度泛函理论进行的对接和理论研究中，实验结果与理论结果之间有很好的一致性。
