Barabash R D, Gukevich E K, Berezovskaia Z V, Varava G N, Levitskiĭ A P
Vopr Med Khim. 1979 May-Jun;25(3):333-42.
In order to study the role of peroxidase in pathogenesis of periodontosis clinical observations were carried out in 132 patients with inflammatory-dystrophic form of periodontal disease and eight species of laboratory and domestic animals were used in experiments. In the patients studied a distinct increase in peroxidase activity was observed in mixed saliva and in gum tissues, which correlated with the severity of the periodontal disease. Inflammatory-dystrophic impairment of cat periodontium was accompanied by an increase in the peroxidase activity only in gum and alveolar process tissues; cats are characterized by the highest amounts of exogenous peroxidase in oral tissues as compared with other laboratory animals. High amounts of exogenous peroxidase did not affect the periododontal tissues of rats during long-term experiments. The main protective effects of the enzyme were as follows: bacteriostatic influence on streptococci in oral cavity and inhibition of leukocyte emifration. Estimation of the peroxidase activity in saliva may be considered as a diagnostic test for periodontosis and may be used to monitore the course of treatment.
为了研究过氧化物酶在牙周病发病机制中的作用，对132例患有炎症 - 营养不良型牙周病的患者进行了临床观察，并在实验中使用了8种实验动物和家畜。在所研究的患者中，混合唾液和牙龈组织中的过氧化物酶活性明显增加，这与牙周病的严重程度相关。猫牙周组织的炎症 - 营养不良性损害仅伴有牙龈和牙槽突组织中过氧化物酶活性的增加；与其他实验动物相比，猫口腔组织中外源过氧化物酶的含量最高。在长期实验中，大量的外源过氧化物酶并未影响大鼠的牙周组织。该酶的主要保护作用如下：对口腔中的链球菌具有抑菌作用，并抑制白细胞渗出。唾液中过氧化物酶活性的测定可被视为牙周病的诊断试验，并可用于监测治疗过程。
