Barabash R D, Levitskiĭ A P, Genesina T I, Konovets V M
Vopr Med Khim. 1976 Nov-Dec;22(6):784-91.
In patients with periodontal disease a distinct increase in secretion of salivary acidic and alkaline RNAases was found. The RNAases activity in mixed saliva correlated with the intensity of degradation of periodontal tissues during loss of alveolar layer in aged Wistar rats and the spontaneous periodontal disease in cats. In experiments with golden hamsters salivary RNAase was found to penetrate through mucosa in active form. The purified salivary RNAase inhibited the protein biosynthesis in rabbit gingiva. Intensive atrophic alterations were produced in periodontal tissues of Wistar rats by means of purified salivary RNAase.
在患有牙周病的患者中，发现唾液酸性和碱性核糖核酸酶的分泌明显增加。混合唾液中的核糖核酸酶活性与老年Wistar大鼠牙槽骨丧失期间牙周组织的降解强度以及猫的自发性牙周病相关。在金黄地鼠实验中，发现唾液核糖核酸酶以活性形式穿透黏膜。纯化的唾液核糖核酸酶抑制兔牙龈中的蛋白质生物合成。通过纯化的唾液核糖核酸酶在Wistar大鼠的牙周组织中产生了严重的萎缩性改变。
