Porter J B, Beard K, Walker A M, Lawson D H, Jick H, Kellaway G S
Arch Intern Med. 1986 Nov;146(11):2237-9.
We studied the frequency of adverse reactions occurring in 1189 patients who received cimetidine intravenously, based on data collected as part of a hospital-based monitoring study of recently marketed drugs. There were 40 patients (3.4%) with adverse reactions, 23 of whom were considered to be "definitely" or "probably" related to cimetidine use and 17 patients in whom a causal association was possible. The most frequently reported reactions were neuropsychiatric disorders in 19 patients (1.6%) and leukopenia in eight patients (0.7%).
我们根据一项针对近期上市药物的医院监测研究收集的数据，研究了1189例静脉注射西咪替丁患者的不良反应发生频率。有40例患者（3.4%）出现不良反应，其中23例被认为“肯定”或“很可能”与使用西咪替丁有关，17例患者可能存在因果关联。最常报告的反应是19例患者（1.6%）出现神经精神障碍，8例患者（0.7%）出现白细胞减少。
