Baska R S, Moses F M, Deuster P A
Human Performance Laboratory, Uniformed Services University of the Health Sciences, Bethesda, Maryland.
Dig Dis Sci. 1990 Aug;35(8):956-60. doi: 10.1007/BF01537243.
A prospective observational study was undertaken to compare the effect of cimetidine usage immediately before and during a 100-mile running race on the frequency of detectable gastrointestinal bleeding and to relate these data to the frequency and intensity of gastrointestinal symptoms and to training data collected from pre- and postrace questionnaires. Nine of 25 runners in the 1989 Old Dominion 100-mile Endurance Race took 800 mg of cimetidine 1 hr before the start and at 50 miles. Sixteen other runners acted as controls and were not different in age, gender, or training data. All runners also submitted three stool specimens from the week before the race and from the first three bowel movements after the race on standard Hemoccult cards. All runners were Hemoccult negative before the race. One of the 9 (11%) cimetidine runners and 14 of the 16 (87.5%) control runners were Hemoccult positive afterwards (P less than or equal to 0.05). Nausea and vomiting were less in those runners taking cimetidine (P less than or equal to 0.05). There was no difference in the race performance as related to the ability to finish or in the number of miles run during the race. This study may help to define the etiology of this common gastrointestinal bleeding in these ultradistance runners and may be useful in preventing some of the symptoms associated with long-distance running.
进行了一项前瞻性观察研究，以比较在100英里长跑比赛前及比赛期间立即使用西咪替丁对可检测到的胃肠道出血频率的影响，并将这些数据与胃肠道症状的频率和强度以及从赛前和赛后问卷收集的训练数据相关联。在1989年旧自治领100英里耐力赛的25名跑步者中，9人在比赛开始前1小时和50英里处服用了800毫克西咪替丁。另外16名跑步者作为对照，在年龄、性别或训练数据方面没有差异。所有跑步者还在标准潜血卡上提交了比赛前一周以及比赛后前三次排便的三份粪便样本。所有跑步者在比赛前潜血检查均为阴性。赛后，9名服用西咪替丁的跑步者中有1名（11%）潜血检查呈阳性，16名对照跑步者中有14名（87.5%）潜血检查呈阳性（P≤0.05）。服用西咪替丁的跑步者恶心和呕吐症状较少（P≤0.05）。在完赛能力或比赛期间跑过的英里数方面，比赛表现没有差异。这项研究可能有助于确定这些超长距离跑步者中这种常见胃肠道出血的病因，并且可能有助于预防一些与长跑相关的症状。
