Stier Andrew J, Cardenas-Iniguez Carlos, Kardan Omid, Moore Tyler M, Meyer Francisco A C, Rosenberg Monica D, Kaczkurkin Antonia N, Lahey Benjamin B, Berman Marc G
Department of Psychology, University of Chicago.
Department of Psychiatry, University of Pennsylvania.
Netw Neurosci. 2023 Oct 1;7(3):1153-1180. doi: 10.1162/netn_a_00322. eCollection 2023.
The Hurst exponent () isolated in fractal analyses of neuroimaging time series is implicated broadly in cognition. Within this literature, is associated with multiple mental disorders, suggesting that is transdimensionally associated with psychopathology. Here, we unify these results and demonstrate a pattern of decreased with increased general psychopathology and attention-deficit/hyperactivity factor scores during a working memory task in 1,839 children. This pattern predicts current and future cognitive performance in children and some psychopathology in 703 adults. This pattern also defines psychological and functional axes associating psychopathology with an imbalance in resource allocation between fronto-parietal and sensorimotor regions, driven by reduced resource allocation to fronto-parietal regions. This suggests the hypothesis that impaired working memory function in psychopathology follows from a reduced cognitive resource pool and a reduction in resources allocated to the task at hand.
在神经影像时间序列的分形分析中分离出的赫斯特指数（）广泛涉及认知。在该文献中，与多种精神障碍相关，表明与精神病理学存在跨维度关联。在此，我们整合这些结果，并证明在1839名儿童的工作记忆任务中，随着总体精神病理学和注意力缺陷/多动因子得分的增加，赫斯特指数呈下降趋势。这种模式可预测儿童当前和未来的认知表现以及703名成年人的一些精神病理学情况。这种模式还定义了心理和功能轴，将精神病理学与额顶叶和感觉运动区域之间资源分配的不平衡联系起来，这种不平衡是由额顶叶区域资源分配减少所驱动的。这提示了一个假说，即精神病理学中工作记忆功能受损源于认知资源池减少以及分配给手头任务的资源减少。
