Hansen Justine Y, Markello Ross D, Vogel Jacob W, Seidlitz Jakob, Bzdok Danilo, Misic Bratislav
McConnell Brain Imaging Centre, Montréal Neurological Institute, McGill University, Montréal, Québec, Canada.
Department of Psychiatry, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA, USA.
Nat Hum Behav. 2021 Sep;5(9):1240-1250. doi: 10.1038/s41562-021-01082-z. Epub 2021 Mar 25.
Regulation of gene expression drives protein interactions that govern synaptic wiring and neuronal activity. The resulting coordinated activity among neuronal populations supports complex psychological processes, yet how gene expression shapes cognition and emotion remains unknown. Here, we directly bridge the microscale and macroscale by mapping gene expression patterns to functional activation patterns across the cortical sheet. Applying unsupervised learning to the Allen Human Brain Atlas and Neurosynth databases, we identify a ventromedial-dorsolateral gradient of gene assemblies that separate affective and perceptual domains. This topographic molecular-psychological signature reflects the hierarchical organization of the neocortex, including systematic variations in cell type, myeloarchitecture, laminar differentiation and intrinsic network affiliation. In addition, this molecular-psychological signature strengthens over neurodevelopment and can be replicated in two independent repositories. Collectively, our results reveal spatially covarying transcriptomic and cognitive architectures, highlighting the influence that molecular mechanisms exert on psychological processes.
基因表达的调控驱动着蛋白质相互作用，这些相互作用控制着突触连接和神经元活动。神经元群体之间由此产生的协同活动支持着复杂的心理过程，然而基因表达如何塑造认知和情感仍然未知。在这里，我们通过将基因表达模式映射到整个皮质层的功能激活模式，直接在微观和宏观层面之间架起了桥梁。将无监督学习应用于艾伦人类大脑图谱和神经合成数据库，我们识别出一个将情感和感知领域分开的基因组合的腹内侧-背外侧梯度。这种地形学分子-心理特征反映了新皮层的层次组织，包括细胞类型、髓鞘结构、层分化和内在网络归属的系统变化。此外，这种分子-心理特征在神经发育过程中增强，并且可以在两个独立的数据库中复制。总体而言，我们的结果揭示了空间上共变的转录组学和认知结构，突出了分子机制对心理过程的影响。
