Wakako Soshi, Hori Yumiko, Kinoshita Tomokazu, Saiki Takao, Qi Xinyi, Hasegawa Koki, Imai Yoshitane, Mori Tadashi, Nakagawa Keiichi, Fukuhara Gaku
Department of Chemistry, Tokyo Institute of Technology, 2-12-1 Ookayama, Meguro-ku, Tokyo 152-8551, Japan.
Department of Precision Engineering, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-8656, Japan.
ACS Macro Lett. 2023 Oct 17;12(10):1389-1395. doi: 10.1021/acsmacrolett.3c00427. Epub 2023 Oct 2.
Stimulus-responsive polymer materials are an attractive alternative to conventional supramolecular and polymer assemblies for applications in sensing, imaging, and drug-delivery systems. Herein, we synthesized a series of pyrene-labeled α- and ε-poly-l-lysine conjugates with varying degrees of substitution (DSs). Hydrostatic-pressure-UV/vis, fluorescence, and excitation spectroscopies and fluorescence lifetime measurements revealed ground-state conformers and excited-state ensembles emitting fluorescence with variable intensities. The polylysine-based chemosensors demonstrated diverse ratiometric responses to hydrostatic pressure through adjustments in polar solvents, DSs, and polymer backbones. Additionally, the fluorescence chemosensor exhibited a promising value of 3.2 × 10, indicating potential applications in chiral fluorescent materials. This study offers valuable insights into the development of smart hydrostatic-pressure-responsive polymer materials.
刺激响应性聚合物材料是传统超分子和聚合物组装体在传感、成像和药物递送系统应用中的一种有吸引力的替代方案。在此，我们合成了一系列具有不同取代度（DSs）的芘标记的α-和ε-聚-L-赖氨酸共轭物。静水压紫外/可见光谱、荧光光谱、激发光谱以及荧光寿命测量揭示了发射具有可变强度荧光的基态构象体和激发态集合体。基于聚赖氨酸的化学传感器通过在极性溶剂、取代度和聚合物主链方面的调整，对静水压表现出多样的比率响应。此外，该荧光化学传感器表现出有前景的3.2×10的值，表明在手性荧光材料方面具有潜在应用。这项研究为智能静水压响应性聚合物材料的开发提供了有价值的见解。
