Matsumoto Kotaro, Nakagawa Keiichi, Asanuma Daisuke, Fukuhara Gaku
Department of Chemistry, Tokyo Institute of Technology, Tokyo, Japan.
Department of Bioengineering, The University of Tokyo, Tokyo, Japan.
Front Chem. 2024 Oct 7;12:1478034. doi: 10.3389/fchem.2024.1478034. eCollection 2024.
In current chemistry, supramolecular materials that respond to a wide variety of external stimuli, such as solvents, temperature, light excitation, pH, and mechanical forces (pressure, stress, strain, and tension), have attracted considerable attention; for example, we have developed cyclodextrins, cucurbiturils, pillararenes, calixarenes, crown ether-based chemical sensors, or chemosensors. These supramolecular chemosensors have potential applications in imaging, probing, and cancer detection. Recently, we focused on pressure, particularly solution-state hydrostatic pressure, from the viewpoint of cancer therapy. This Mini Review summarizes (i) why hydrostatic pressure is important, particularly in biology, and (ii) what we can do using hydrostatic pressure stimulation.
在当前化学领域，能够响应多种外部刺激（如溶剂、温度、光激发、pH值和机械力（压力、应力、应变和张力））的超分子材料已引起了广泛关注；例如，我们已开发出基于环糊精、葫芦脲、柱芳烃、杯芳烃、冠醚的化学传感器或化学传感剂。这些超分子化学传感剂在成像、探测和癌症检测方面具有潜在应用。最近，我们从癌症治疗的角度关注压力，特别是溶液态静水压力。本综述总结了（i）静水压力为何重要，尤其是在生物学中，以及（ii）利用静水压力刺激我们能做什么。
