食管鳞癌中的肿瘤相关巨噬细胞：有前途的治疗意义。
Tumor associated macrophages in esophageal squamous carcinoma: Promising therapeutic implications.
机构信息
Department of Thoracic Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, China; Department of Thoracic Surgery, School of Medicine, South China University of Technology, Guangzhou, China.
Department of Thoracic Surgery, the Sixth Medical Center of PLA General Hospital, Beijing, China.
出版信息
Biomed Pharmacother. 2023 Nov;167:115610. doi: 10.1016/j.biopha.2023.115610. Epub 2023 Sep 30.
Esophageal squamous carcinoma (ESCC) is a prevalent and highly lethal malignant tumor, with a five-year survival rate of approximately 20 %. Tumor-associated macrophages (TAMs) are the most prominent immune cells in the tumor microenvironment (TME), comprising over 50 % of the tumor volume. TAMs can be polarized into two distinct phenotypes, M1-type and M2-type, through interactions with cancer cells. M2-type TAMs are more abundant than M1-type TAMs in the TME, contributing to tumor progression, such as tumor cell survival and the construction of an immunosuppressive environment. This review focuses on the role of TAMs in ESCC, including their polarization, impact on tumor proliferation, angiogenesis, invasion, migration, therapy resistance, and immunosuppression. In addition, we discuss the potential of targeting TAMs for clinical therapy in ESCC. A thorough comprehension of the molecular biology about TAMs is essential for the development of innovative therapeutic strategies to treat ESCC.
食管鳞状细胞癌（ESCC）是一种常见且致命的恶性肿瘤，五年生存率约为 20%。肿瘤相关巨噬细胞（TAMs）是肿瘤微环境（TME）中最主要的免疫细胞，占肿瘤体积的 50%以上。TAMs 可以通过与癌细胞相互作用而极化为两种截然不同的表型，M1 型和 M2 型。在 TME 中，M2 型 TAMs 比 M1 型 TAMs 更为丰富，有助于肿瘤的进展，如肿瘤细胞的存活和免疫抑制环境的构建。本综述重点讨论了 TAMs 在 ESCC 中的作用，包括其极化、对肿瘤增殖、血管生成、侵袭、迁移、治疗抵抗和免疫抑制的影响。此外，我们还讨论了针对 TAMs 进行临床治疗 ESCC 的潜力。深入了解 TAMs 的分子生物学对于开发治疗 ESCC 的创新治疗策略至关重要。
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