UH Rainbow Babies & Children's Hospital and Case Western Reserve University, Cleveland, OH.
UH Rainbow Babies & Children's Hospital and Case Western Reserve University, Cleveland, OH.
Semin Perinatol. 2023 Oct;47(6):151819. doi: 10.1016/j.semperi.2023.151819. Epub 2023 Sep 9.
Bronchopulmonary dysplasia (BPD) is a disease exclusive to prematurity and has changed in its definition since Northway first described it in 1967. There have been countless clinical trials evaluating the efficacy of drugs in the treatment and prevention of BPD in human subjects, and an even larger number of animal studies. Despite these, only a handful of drugs are used at the bedside today, primarily due to the lack of consistent efficacy seen in clinical trials or due to reports of adverse effects. This review summarizes the list of the most commonly used drugs and emerging new therapies which target BPD and BPD-related pulmonary hypertension (BPD-PH), including those which have shown promise in human trials but are not yet used routinely.
支气管肺发育不良（BPD）是一种早产儿特有的疾病，自 Northway 于 1967 年首次描述以来，其定义已经发生了变化。已经有无数临床试验评估了药物在人类 BPD 治疗和预防中的疗效，还有更多的动物研究。尽管如此，目前只有少数几种药物在临床上使用，主要是由于临床试验中观察到的疗效不一致，或者由于报告了不良反应。这篇综述总结了目前常用于治疗 BPD 和 BPD 相关肺动脉高压（BPD-PH）的最常用药物和新兴治疗方法，包括在人类试验中显示出前景但尚未常规使用的药物。
