Sang Yating, Qiao Lina
Pediatric Intensive Care Unit, West China Second University Hospital, Sichuan University, Chengdu, China.
Key Laboratory of Birth Defects and Related Diseases of Women and Children, Ministry of Education, Sichuan University, Chengdu, China.
Front Cell Dev Biol. 2024 Sep 3;12:1462841. doi: 10.3389/fcell.2024.1462841. eCollection 2024.
Bronchopulmonary dysplasia (BPD) is fundamentally characterized by the arrest of lung development and abnormal repair mechanisms, which result in impaired development of the alveoli and microvasculature. Hepatocyte growth factor (HGF), secreted by pulmonary mesenchymal and endothelial cells, plays a pivotal role in the promotion of epithelial and endothelial cell proliferation, branching morphogenesis, angiogenesis, and alveolarization. HGF exerts its beneficial effects on pulmonary vascular development and alveolar simplification primarily through two pivotal pathways: the stimulation of neovascularization, thereby enriching the pulmonary microvascular network, and the inhibition of the epithelial-mesenchymal transition (EMT), which is crucial for maintaining the integrity of the alveolar structure. We discuss HGF and its receptor c-Met, interact with various growth factors throughout the process of lung development and BPD, and form a signaling network with HGF as a hub, which plays the pivotal role in orchestrating and integrating epithelial, endothelial and mesenchymal.
支气管肺发育不良（BPD）的根本特征是肺发育停滞和异常修复机制，这导致肺泡和微血管发育受损。肺间充质细胞和内皮细胞分泌的肝细胞生长因子（HGF）在促进上皮细胞和内皮细胞增殖、分支形态发生、血管生成和肺泡化方面起关键作用。HGF主要通过两条关键途径对肺血管发育和肺泡简化发挥有益作用：刺激新血管形成，从而丰富肺微血管网络；抑制上皮-间质转化（EMT），这对维持肺泡结构的完整性至关重要。我们讨论了HGF及其受体c-Met，它们在肺发育和BPD的整个过程中与各种生长因子相互作用，并形成以HGF为中心的信号网络，该网络在协调和整合上皮细胞、内皮细胞和间充质细胞方面起关键作用。
