Department of Nephrology, Xijing Hospital, The Fourth Military Medical University, Changle Road, No. 127 Changle West Road, Xi'an, Shaanxi, China.
Department of Geriatrics, Xijing Hospital, The Fourth Military Medical University, Changle Road, No. 127 Changle West Road, Xi'an, Shaanxi, China.
Cell Commun Signal. 2023 Oct 2;21(1):270. doi: 10.1186/s12964-023-01262-6.
The abnormal lipid and glucose metabolisms are linked to the metabolic disorders, tumorigenesis, and fibrotic diseases, which attracts the increasing attention to find out the key molecules involved in the lipid and glucose metabolism as the possible therapeutic targets on these diseases. A transcriptional factor Twist1 has been associated with not only the embryonic development, cancer, and fibrotic diseases, but also the regulation of lipid and glucose metabolism. In this review, we will discuss the roles and mechanisms of Twist1 in the obesity-associated white adipose tissue inflammation and insulin resistance, brown adipose tissue metabolism, fatty acid oxidation, and glucose metabolism in skeletal muscle to provide a rational perspective to consider Twist1 as a potential treatment target in clinic. Video Abstract.
异常的脂质和葡萄糖代谢与代谢紊乱、肿瘤发生和纤维化疾病有关，这引起了人们越来越多的关注，以寻找参与脂质和葡萄糖代谢的关键分子作为这些疾病的可能治疗靶点。转录因子 Twist1 不仅与胚胎发育、癌症和纤维化疾病有关，而且与脂质和葡萄糖代谢的调节有关。在这篇综述中，我们将讨论 Twist1 在肥胖相关的白色脂肪组织炎症和胰岛素抵抗、棕色脂肪组织代谢、脂肪酸氧化和骨骼肌葡萄糖代谢中的作用和机制，为将 Twist1 作为一种潜在的临床治疗靶点提供合理的视角。视频摘要。
