免疫性血小板减少症中的高脂血症：一项回顾性研究。
Hyperlipidemia in immune thrombocytopenia: a retrospective study.
作者信息
Han Shouqing, Lu Hui, Yu Yafei, Liu Xinguang, Jing Fangmiao, Wang Liang, Zhao Yajing, Hou Ming
机构信息
Department of Hematology, Qilu Hospital of Shandong University, 107 West Wenhua Road, Jinan, 250012, Shandong, China.
Shandong Provincial Key Laboratory of Immunohematology, Qilu Hospital of Shandong University, Jinan, China.
出版信息
Thromb J. 2023 Oct 2;21(1):102. doi: 10.1186/s12959-023-00545-9.
BACKGROUND
Immune thrombocytopenia (ITP) is an autoimmune hemorrhagic disease characterized by low platelet count and bleeding manifestations. However, some patients also suffered from atherosclerosis or even infarction. Apart from activated platelets, lipid metabolism takes a large part in the formation of atherosclerosis and metabolic syndrome. The lipid metabolic state in ITP patients is still unknown.
METHODS
We retrospectively reviewed 302 hospitalized ITP patients in our cohort, comparing their blood lipids, bleeding symptoms, metabolic diseases and treatment responses.
RESULTS
We found a high proportion of ITP patients suffered from hyperlipidemia, and other metabolic diseases including cardiovascular or cerebral atherosclerosis or infarction, hypertension, and type 2 diabetes. Hyperlipidemia was associated with severe bleeding and treatment refractoriness in ITP. Statins could alleviate thrombocytopenia and bleeding severity, and facilitate ITP treatment, while improving hyperlipidemia in ITP patients.
CONCLUSIONS
Our present study demonstrated that lipid metabolism might play an indispensable role in ITP pathogenesis and development.
背景
免疫性血小板减少症（ITP）是一种自身免疫性出血性疾病，其特征为血小板计数低和出血表现。然而，一些患者还患有动脉粥样硬化甚至梗死。除了活化的血小板外，脂质代谢在动脉粥样硬化和代谢综合征的形成中起很大作用。ITP患者的脂质代谢状态仍不清楚。
方法
我们回顾性分析了队列中302例住院ITP患者，比较了他们的血脂、出血症状、代谢性疾病和治疗反应。
结果
我们发现高比例的ITP患者患有高脂血症以及其他代谢性疾病，包括心血管或脑动脉粥样硬化或梗死、高血压和2型糖尿病。高脂血症与ITP中的严重出血和治疗难治性相关。他汀类药物可以减轻血小板减少症和出血严重程度，促进ITP治疗，同时改善ITP患者的高脂血症。
结论
我们目前的研究表明，脂质代谢可能在ITP的发病机制和发展中起不可或缺的作用。
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