Rauca C, Matthies H
Biomed Biochim Acta. 1986;45(8):1083-91.
After unilateral striatal application the tyrosine-containing and Des-tyrosine analogues of beta-casomorphin were investigated with regard to the properties inducing rotational behaviour in rats. The tyrosine-containing beta-casomorphins (D-Pro4)-beta-casomorphin1-5, (D-Phe3)-beta-casomorphin1-5 or (D-Pip4)-beta-casomorphin1-5 produced contralateral rotations like apomorphine, whereas the Des-tyrosine-beta-casomorphins brought about an ipsilateral haloperidol-like asymmetry; (Des-Tyr1-D-Pip4)-beta-casomorphin2-5 did not evoke a lateralization of motor behaviour. The contralateral turning following unilateral apomorphine application into striatum was increased by striatal administration of tyrosine-containing beta-casomorphin analogues and antagonistically influenced by (Des-Tyr1-D-Pro4)-beta-casomorphin2-5 or (Des-Tyr1-D-Phe3)-beta-casomorphin2-5; however, (Des-Tyr1-D-Pip4)-beta-casomorphin2-5 has no effect on apomorphine-induced rotation behaviour. The time course of the animals' asymmetric motor behaviour after striatal apomorphine administration was antagonistically influenced by haloperidol, (Des-Tyr1-D-Phe3)-beta-casomorphin2-5 or (Des-Tyr1-D-Pro4)-beta-casomorphin2-5; quantitative differences were observed as far as the strength and the duration of the apomorphine antagonistic effect of Des-Tyr-beta-casomorphins are concerned.
在单侧纹状体给药后，研究了含酪氨酸的β-酪蛋白吗啡类似物和去酪氨酸类似物诱导大鼠旋转行为的特性。含酪氨酸的β-酪蛋白吗啡（D-脯氨酸4）-β-酪蛋白吗啡1-5、（D-苯丙氨酸3）-β-酪蛋白吗啡1-5或（D-哌啶4）-β-酪蛋白吗啡1-5产生与阿扑吗啡类似的对侧旋转，而去酪氨酸-β-酪蛋白吗啡则引起同侧氟哌啶醇样不对称；（去酪氨酸1-D-哌啶4）-β-酪蛋白吗啡2-5未引起运动行为的侧化。将含酪氨酸的β-酪蛋白吗啡类似物纹状体给药可增加单侧阿扑吗啡注入纹状体后产生的对侧旋转，并受到（去酪氨酸1-D-脯氨酸4）-β-酪蛋白吗啡2-5或（去酪氨酸1-D-苯丙氨酸3）-β-酪蛋白吗啡2-5的拮抗影响；然而，（去酪氨酸1-D-哌啶4）-β-酪蛋白吗啡2-5对阿扑吗啡诱导的旋转行为无影响。纹状体注射阿扑吗啡后动物不对称运动行为的时间进程受到氟哌啶醇、（去酪氨酸1-D-苯丙氨酸3）-β-酪蛋白吗啡2-5或（去酪氨酸1-D-脯氨酸4）-β-酪蛋白吗啡2-5的拮抗影响；就去酪氨酸-β-酪蛋白吗啡对阿扑吗啡拮抗作用的强度和持续时间而言，观察到了定量差异。
