修饰酪蛋白吗啡对大鼠打哈欠行为的影响。

Influence of modified casomorphins on yawning behavior of rats.

作者信息

Rüthrich H L, Grecksch G, Matthies H

机构信息

Institute of Pharmacology and Toxicology, Medical Academy, Magdeburg, FRG.

出版信息

Peptides. 1992 Jan-Feb;13(1):69-72. doi: 10.1016/0196-9781(92)90141-o.

DOI:10.1016/0196-9781(92)90141-o

PMID:1620658

Abstract

Apomorphine-induced yawning was completely suppressed in animals treated with 5 nmol [D-Pro4]casomorphin (CM) (ICV), 10 nmol [D-Phe3]CM (ICV) or 10 nmol [D-Pip4]CM (ICV). The apomorphine-induced yawning was also decreased, by des-Tyr analogs, but only by about 50%. Physostigmine (0.15 mg/kg, IP) induced yawning. The physostigmine-induced yawning was suppressed by 5 nmol [D-Pro4]CM and 10 nmol [D-Phe3]CM. Both [des-Tyr-D-Phe3]CM and [des-Tyr-D-Pip4]CM were without effect, whereas [des-Tyr-D-Pro4]CM increased significantly the physostigmine-induced yawning. The results suggest that dopaminergic transmission can be modulated by beta-casomorphin derivatives, thus resulting in a decrease in yawning. In the case of the des-tyrosine derivatives, we can assume a dopaminergic modulation, too. An increase in serotonergic activity might be supposed for [des-Tyr-D-Pro4]CM.

摘要

在用5纳摩尔[D-脯氨酸4]酪蛋白吗啡（CM）（脑室内注射）、10纳摩尔[D-苯丙氨酸3]CM（脑室内注射）或10纳摩尔[D-哌啶4]CM（脑室内注射）处理的动物中，阿扑吗啡诱导的呵欠完全被抑制。阿扑吗啡诱导的呵欠也被去酪氨酸类似物降低，但仅降低约50%。毒扁豆碱（0.15毫克/千克，腹腔注射）诱导呵欠。毒扁豆碱诱导的呵欠被5纳摩尔[D-脯氨酸4]CM和10纳摩尔[D-苯丙氨酸3]CM抑制。[去酪氨酸-D-苯丙氨酸3]CM和[去酪氨酸-D-哌啶4]CM均无作用，而[去酪氨酸-D-脯氨酸4]CM显著增加毒扁豆碱诱导的呵欠。结果表明，多巴胺能传递可被β-酪蛋白吗啡衍生物调节，从而导致呵欠减少。对于去酪氨酸衍生物，我们也可以假定存在多巴胺能调节。对于[去酪氨酸-D-脯氨酸4]CM，可能存在5-羟色胺能活性增加。