Sim A K, McCraw A P, Cleland M E, Aihara H, Otomo S, Hosoda K
Arzneimittelforschung. 1986 Aug;36(8):1206-9.
Prostaglandin E1 incorporated in lipid microspheres (lipo-PGE1) was evaluated following intravenous administration as an inhibitor of ADP-induced thrombus growth rate and as a thrombus disaggregating agent following vascular damage in the microcirculation of the hamster cheek pouch. The drug was shown to be significantly more active and longer acting than PGE1 in the first experiment. Following vascular damage lipo-PGE1 was very efficacious as a thrombus disaggregating agent and was significantly more effective when infused after, rather than before, vascular damage. These data suggested that the drug might be targeted to the site of damage. When incorporated in lipid microspheres, PGE1 appeared to be more stable, longer acting and more efficacious than PGE1 alone.
脂质微球包裹的前列腺素E1（脂微球PGE1）经静脉给药后，作为一种抑制ADP诱导的血栓生长速率的药物，以及作为仓鼠颊囊微循环血管损伤后血栓解体剂进行了评估。在第一个实验中，该药物显示出比PGE1活性显著更高且作用时间更长。血管损伤后，脂微球PGE1作为血栓解体剂非常有效，并且在血管损伤后而不是损伤前注入时效果显著更好。这些数据表明该药物可能靶向损伤部位。当包裹在脂质微球中时，PGE1似乎比单独的PGE1更稳定、作用时间更长且更有效。
