Carvalho Suzana Gonçalves, Dos Santos Aline Martins, Polli Silvestre Amanda Letícia, Tavares Alberto Gomes, Chorilli Marlus, Daflon Gremião Maria Palmira
Department of Drugs and Medicines, School of Pharmaceutical Sciences - São Paulo State University (UNESP), Araraquara, Brazil.
Expert Opin Drug Deliv. 2023 Jul-Dec;20(9):1231-1249. doi: 10.1080/17425247.2023.2263360. Epub 2023 Oct 17.
Innovative delivery systems are a promising and attractive approach for drug targeting in pharmaceutical technology. Among the various drug delivery systems studied, the association of strategies based on nanoparticles and microparticles, called nano-in-microparticles, has been gaining prominence as it allows targeting in a specific and personalized way, considering the physiological barriers faced in each disease.
This review proposes to discuss nano-in-micro systems, updated progress on the main biomaterials used in the preparation of these systems, preparation techniques, physiological considerations, applications and challenges, and possible strategies for drug administration. Finally, we bring future perspectives for advances in clinical and field translation of multifunctional systems based on nano-in-microparticles.
This article brings a new approach to exploring the use of multifunctional systems based on nano-in-microparticles for different applications, in addition, it also emphasizes the use of biomaterials in these systems and their limitations. There is currently no study in the literature that explores this approach, making a review article necessary to address this association of strategies for application in pharmaceutical technology.
创新给药系统是药物技术中药物靶向的一种有前景且具吸引力的方法。在研究的各种药物递送系统中，基于纳米颗粒和微粒的策略组合，即所谓的纳米包入微粒，正日益受到关注，因为考虑到每种疾病所面临的生理屏障，它能够以特定且个性化的方式实现靶向。
本综述旨在讨论纳米包入微粒系统、制备这些系统所使用的主要生物材料的最新进展、制备技术、生理考量、应用与挑战以及给药的可能策略。最后，我们展望基于纳米包入微粒的多功能系统在临床和领域转化方面取得进展的未来前景。
本文提出了一种探索基于纳米包入微粒的多功能系统用于不同应用的新方法，此外，还强调了这些系统中生物材料的使用及其局限性。目前文献中尚无研究探索此方法，因此有必要撰写一篇综述文章来阐述这种策略组合在药物技术中的应用。
