Marmara University, Faculty of Pharmacy, Department of Pharmaceutical Biotechnology, 34668, Istanbul, Turkey.
Expert Opin Drug Deliv. 2012 Sep;9(9):1129-46. doi: 10.1517/17425247.2012.702752. Epub 2012 Jul 9.
Topical drug delivery offers important benefits for improving the therapeutic effect and reducing systemic side effects of the administered compounds. In addition, utilization of biopolymeric material-based systems can play a key role in developing new topical dosage forms and their applications. This review describes the advances that have been made, new strategies and as well as possible challenges of particular systems of chitosan used in topical drug delivery, including challenging innovations in topical usage of these systems that can make significant impact on clinical practice.
The main area covered is hypothesis that particulate carriers based on chitosan and its derivatives can penetrate the topical barriers from the body. For this reason, the novel studies described emphasize the fact that chitosan-based particular systems are popular that can be tailor-made according to in vitro and in vivo characterization. Such parameters, which are known to influence their in vivo performance, can be modulated by adjusting the formulation conditions of the chitosan-based particular systems for topical application.
The topical application of drugs with particulate systems comprising a natural polymer, chitosan, is one of the most popular drug delivery routes. The aim of topical use of chitosan particles is to improve the drug bioavailability by prolonging the residence time of drugs applied topically or by enhancing the passing of drugs through the epithelial cells by opening the tight junctions between epithelial cells and also to reduce the side effects of the drugs.
局部药物递送为提高所施用化合物的治疗效果和减少全身副作用提供了重要益处。此外，利用基于生物聚合物材料的系统可以在开发新的局部剂型及其应用方面发挥关键作用。本综述描述了在局部药物递送中使用壳聚糖的特定系统的进展、新策略以及可能的挑战，包括这些系统在局部应用方面具有挑战性的创新，这些创新可能对临床实践产生重大影响。
主要涵盖的领域是基于壳聚糖及其衍生物的颗粒载体可以穿透身体的局部屏障的假设。出于这个原因，所描述的新研究强调了这样一个事实，即基于壳聚糖的特殊系统很受欢迎，可以根据体外和体内特性进行定制。可以通过调整用于局部应用的基于壳聚糖的特殊系统的配方条件来调节这些已知会影响其体内性能的参数。
包含天然聚合物壳聚糖的颗粒系统的药物局部应用是最受欢迎的药物递送途径之一。壳聚糖颗粒局部应用的目的是通过延长局部应用药物的停留时间或通过打开上皮细胞之间的紧密连接增强药物通过上皮细胞的传递来提高药物的生物利用度，还可以减少药物的副作用。
