Department of Biotherapy, Cancer Center and State Key Laboratory of Biotherapy, West China Hospital, Sichuan University, Chengdu, 610041, China.
Department of Cardiovascular Surgery, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University, Chengdu, 610041, China.
Adv Healthc Mater. 2024 Feb;13(5):e2303042. doi: 10.1002/adhm.202303042. Epub 2023 Oct 15.
The healing of chronic diabetic wounds is a common and significant challenge in the medical field. Despite extensive efforts, the development of hydrogel dressings with satisfactory functionality remains an ongoing concern. In this study, a multifunctional hydrogel wound dressing (PAN/Ag-PLG) with adhesion, antibacterial, hemostatic, and other properties, which can effectively repair diabetic wounds infected with methicillin-resistant Staphylococcus aureus (MRSA), is presented. The hydrogel dressing is composed of gallic acid (GA)-functionalized polylysine (PL)-reduced silver nanoparticles (Ag-PLG), oxidized hyaluronic acid (OHA), and cross-linked polyacrylic acid grafted with N-hydrosuccinimide ester. Notably, compared to most conventional wound dressing that lack adhesion or are difficult to remove, the prepared hydrogels exhibit excellent adhesion and mild stimulation-triggered detachment. In vitro and in vivo experiments reveal that the PAN/Ag-PLG hydrogel exhibits outstanding biocompatibility and antibacterial properties and promotes diabetic wound repair by reducing oxidative damage and promoting cell migration and angiogenesis. The smart PAN/Ag-PLG hydrogel reported in this study provides an approach for the potential clinical development of painless antibacterial dressings.
慢性糖尿病伤口的愈合是医学领域中的一个常见且重大的挑战。尽管已经进行了广泛的努力，但仍在持续关注开发具有令人满意功能的水凝胶敷料。在这项研究中，提出了一种具有粘附性、抗菌性、止血性和其他性能的多功能水凝胶伤口敷料（PAN/Ag-PLG），可有效修复感染耐甲氧西林金黄色葡萄球菌（MRSA）的糖尿病伤口。水凝胶敷料由没食子酸（GA）功能化聚赖氨酸（PL）还原的银纳米粒子（Ag-PLG）、氧化透明质酸（OHA）和接枝 N-琥珀酰亚胺酯的交联聚丙烯酸组成。值得注意的是，与大多数缺乏粘附性或难以去除的传统伤口敷料相比，所制备的水凝胶表现出优异的粘附性和温和的刺激触发分离性。体外和体内实验表明，PAN/Ag-PLG 水凝胶具有出色的生物相容性和抗菌性能，并通过减少氧化损伤、促进细胞迁移和血管生成来促进糖尿病伤口的修复。本研究中报道的智能 PAN/Ag-PLG 水凝胶为无痛抗菌敷料的潜在临床开发提供了一种方法。
