Fuhrmann G, Besnard F, Kempf J, Kempf E, Ebel A
Alcohol. 1986 Sep-Oct;3(5):291-8. doi: 10.1016/0741-8329(86)90004-2.
Cholinergic neurotransmission has been followed in striatum and hippocampus in two inbred strains of mice (C57Bl/6 and Balb/c) during long term alcohol exposure (over a 25 month period) and with aging. Marked strain dependent differences in reactivity of pre- and postsynaptic cholinergic markers to chronic alcohol exposure and aging were demonstrated in both structures. The Balb/c strain exhibits a remarkable long lasting tolerance to alcohol injury for striatal and hippocampal cholinergic markers (choline acetyltransferase, high affinity choline uptake, muscarinic receptors affinity, acetyl cholinesterase), whereas C57Bl mice appear more sensitive to alcohol intoxication. Likewise aging affects the C57Bl mouse more severely than the Balb/c, a phenomenon which may be involved in the sensitivity of these mice to alcohol intoxication. Moreover long term alcohol exposure, in addition to aging show unequal effects on the diverse cholinergic markers studied. Also divergences of specific brain areas have been noted and should be related to their particular neuroanatomy. Such discrepancies may, in part, explain differences observed in the behavioral effects of chronic alcohol intoxication in alcoholics.
在长期酒精暴露（超过25个月）及衰老过程中，对两种近交系小鼠（C57Bl/6和Balb/c）的纹状体和海马体中的胆碱能神经传递进行了追踪研究。在这两个脑区中，均显示出突触前和突触后胆碱能标志物对慢性酒精暴露及衰老的反应存在明显的品系依赖性差异。Balb/c品系对纹状体和海马体胆碱能标志物（胆碱乙酰转移酶、高亲和力胆碱摄取、毒蕈碱受体亲和力、乙酰胆碱酯酶）的酒精损伤表现出显著的长期耐受性，而C57Bl小鼠似乎对酒精中毒更为敏感。同样，衰老对C57Bl小鼠的影响比对Balb/c小鼠更为严重，这一现象可能与这些小鼠对酒精中毒的敏感性有关。此外，长期酒精暴露除了与衰老外，对所研究的多种胆碱能标志物显示出不同的影响。还注意到特定脑区存在差异，这应与其特定的神经解剖结构有关。这种差异可能部分解释了在酗酒者慢性酒精中毒行为效应中观察到的差异。
