Fuhrmann G, Strosser M T, Besnard F, Kempf E, Kempf J, Ebel A
Neurochem Res. 1986 May;11(5):625-36. doi: 10.1007/BF00965332.
Somatostatin contents of striatum, hippocampus, and pons medulla have been followed in two inbred strains of mice (C57B1/6J and Balb/cJ) with aging and long term alcohol exposure (over a 25 month period of intoxication). Marked strain dependent differences in basic levels of somatostatin and genotypic variations in reactivity of this neuropeptide to aging processes and chronic alcohol exposure were demonstrated. The Balb/c strain exhibits a significant age dependent decrease in striatal and hippocampal somatostatin levels whereas the C57B1 mice remain unchanged until the 27 month. Moreover, only the Balb/c strain reacts to chronic alcohol exposure, showing a significant increase in somatostatin levels in those structures affected by the aging process. Such genotypic differences may be involved in man in specific pathologies in aged individuals and in alcohol induced behavioral alterations in alcoholics.
在两种近交系小鼠（C57B1/6J和Balb/cJ）中，研究了纹状体、海马体和脑桥延髓中生长抑素的含量随衰老和长期酒精暴露（超过25个月的中毒期）的变化情况。结果显示，生长抑素的基础水平存在明显的品系依赖性差异，并且该神经肽对衰老过程和慢性酒精暴露的反应存在基因型变异。Balb/c品系的纹状体和海马体中生长抑素水平呈现出显著的年龄依赖性下降，而C57B1小鼠在27个月前保持不变。此外，只有Balb/c品系对慢性酒精暴露有反应，在那些受衰老过程影响的结构中，生长抑素水平显著升高。这种基因型差异可能在人类中与老年个体的特定病理以及酗酒者酒精诱导的行为改变有关。
