Zhao YaPing, Ai WenJing, Zheng JingFeng, Hu XianLiang, Zhang LuShun
School of Clinical Medicine, Chengdu Medical College, Chengdu, China.
Chengdu Eighth People's Hospital, Geriatric Hospital of Chengdu Medical College, Chengdu, China.
Front Aging Neurosci. 2024 Jan 16;16:1332845. doi: 10.3389/fnagi.2024.1332845. eCollection 2024.
Currently, the prevalence of Alzheimer's disease (AD) is progressively rising, particularly in developed nations. There is an escalating focus on the onset and progression of AD. A mounting body of research indicates that epigenetics significantly contributes to AD and holds substantial promise as a novel therapeutic target for its treatment.
The objective of this article is to present the AD areas of research interest, comprehend the contextual framework of the subject research, and investigate the prospective direction for future research development.
ln Web of Science Core Collection (WOSCC), we searched documents by specific subject terms and their corresponding free words. VOSviewer, CiteSpace and Scimago Graphica were used to perform statistical analysis on measurement metrics such as the number of published papers, national cooperative networks, publishing countries, institutions, authors, co-cited journals, keywords, and visualize networks of related content elements.
We selected 1,530 articles from WOSCC from January 2013 to June 2023 about epigenetics of AD. Based on visual analysis, we could get that China and United States were the countries with the most research in this field. Bennett DA was the most contributed and prestigious scientist. The top 3 cited journals were Journal of Alzheimer's Disease, Neurobiology of Aging and Molecular Neurobiology. According to the analysis of keywords and the frequency of citations, ncRNAs, transcription factor, genome, histone modification, blood DNA methylation, acetylation, biomarkers were hot research directions in AD today.
According to bibliometric analysis, epigenetic research in AD was a promising research direction, and epigenetics had the potential to be used as AD biomarkers and therapeutic targets.
目前，阿尔茨海默病（AD）的患病率正在逐步上升，尤其是在发达国家。人们对AD的发病和进展的关注日益增加。越来越多的研究表明，表观遗传学在AD中起着重要作用，并有望成为其治疗的新靶点。
本文旨在介绍AD的研究热点领域，理解该主题研究的背景框架，并探讨未来研究发展的潜在方向。
在Web of Science核心合集（WOSCC）中，我们通过特定主题词及其相应的自由词搜索文献。使用VOSviewer、CiteSpace和Scimago Graphica对发表论文数量、国家合作网络、发表国家、机构、作者、共被引期刊、关键词等计量指标进行统计分析，并对相关内容元素的网络进行可视化。
我们从WOSCC中选取了2013年1月至2023年6月间关于AD表观遗传学的1530篇文章。通过可视化分析可知，中国和美国是该领域研究最多的国家。贝内特·DA是贡献最大、最具声望的科学家。被引次数排名前三的期刊是《阿尔茨海默病杂志》《衰老神经生物学》和《分子神经生物学》。根据关键词和被引频次分析，非编码RNA、转录因子、基因组、组蛋白修饰、血液DNA甲基化、乙酰化、生物标志物是当今AD研究的热点方向。
根据文献计量分析，AD的表观遗传学研究是一个有前景的研究方向，表观遗传学有潜力用作AD的生物标志物和治疗靶点。
