Zhang Jun-Yan, Steven Z Du, Liao Ke-Hua
Department of Anesthesiology Southwest Medical University Luzhou China.
Department of Integrative Biology University of Wisconsin-Madison Madison Wisconsin USA.
Ibrain. 2023 May 1;9(2):195-204. doi: 10.1002/ibra.12101. eCollection 2023 Summer.
Spinal cord injury (SCI) is a nervous system disease characterized by sensory and motor dysfunction, axonal apoptosis, decreased vascular density, and inflammation. At present, surgical treatment, drug treatment, and cell therapy can be used. Surgical treatment can improve motor and independent function scores, and drug treatment can promote the recovery of neurons in the spinal cord, but only improve symptoms. Complete recovery of SCI has not yet been achieved. However, the differentiation of stem cells brings hope for the treatment of SCI. Umbilical cord blood cells (UCBs) are ethically readily available and can repair neuronal damage. However, it is still unclear how they can improve symptoms and repair nerve severity. In this paper, the role of UCBs in the treatment of SCI is described in detail from different aspects such as behavior, morphology, and molecular expression changes, so as to provide new ideas and theoretical directions for future research.
脊髓损伤（SCI）是一种以感觉和运动功能障碍、轴突凋亡、血管密度降低和炎症为特征的神经系统疾病。目前，可以采用手术治疗、药物治疗和细胞治疗。手术治疗可提高运动和独立功能评分，药物治疗可促进脊髓神经元的恢复，但只能改善症状。SCI尚未实现完全恢复。然而，干细胞的分化为SCI的治疗带来了希望。脐带血细胞（UCBs）在伦理上易于获取，并且可以修复神经元损伤。然而，它们如何改善症状和修复神经严重程度仍不清楚。本文从行为、形态和分子表达变化等不同方面详细描述了UCBs在SCI治疗中的作用，以便为未来的研究提供新的思路和理论方向。
