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一名年轻成年男性因水痘带状疱疹病毒感染导致病毒性脑膜炎的病例。

A case of viral meningitis due to Varicella Zoster virus infection in a young adult male.

作者信息

Nebeluk Nazary, Lukin Robert, Alkayali Talal, Talwani Rohit

机构信息

Department of Internal Medicine, University of Maryland Medical Center, Baltimore, MD, United States.

Division of Infectious Disease, Department of Internal Medicine, University of Maryland Medical Center, Baltimore, MD, United States.

出版信息

IDCases. 2023 Sep 28;34:e01899. doi: 10.1016/j.idcr.2023.e01899. eCollection 2023.

DOI:10.1016/j.idcr.2023.e01899
PMID:37786647
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC10542008/
Abstract

A 36-year-old male with headaches was empirically treated for herpes simplex virus meningitis; CSF PCR testing later confirmed varicella zoster virus meningitis. Valacyclovir was increased to 2 g QID for remaining duration of therapy with full recovery. This case highlights the importance of comprehensive testing and proper treatment adjustment for rarer etiologies of aseptic meningitis.

摘要

一名36岁男性因头痛接受了单纯疱疹病毒性脑膜炎的经验性治疗;脑脊液聚合酶链反应检测后来确诊为水痘带状疱疹病毒性脑膜炎。伐昔洛韦剂量增加至每日4次、每次2克,直至治疗结束,患者完全康复。该病例凸显了对无菌性脑膜炎罕见病因进行全面检测和适当调整治疗的重要性。

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A case of viral meningitis due to Varicella Zoster virus infection in a young adult male.一名年轻成年男性因水痘带状疱疹病毒感染导致病毒性脑膜炎的病例。
IDCases. 2023 Sep 28;34:e01899. doi: 10.1016/j.idcr.2023.e01899. eCollection 2023.
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Varicella-zoster meningitis with a late-onset of skin eruption.水痘-带状疱疹性脑膜炎伴皮疹延迟出现。
BMJ Case Rep. 2015 Feb 17;2015:bcr2014208056. doi: 10.1136/bcr-2014-208056.
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Varicella zoster meningitis complicating combined anti-tumor necrosis factor and corticosteroid therapy in Crohn's disease.水痘带状疱疹性脑膜炎并发克罗恩病的肿瘤坏死因子和皮质类固醇联合治疗。
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引用本文的文献

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Varicella-zoster virus meningitis with hypoglycorrhachia, presenting with painless occipital herpes zoster mimicking atopic dermatitis.水痘-带状疱疹病毒脑膜炎伴脑脊液低糖,表现为无痛性枕部带状疱疹,类似特应性皮炎。
BMJ Case Rep. 2025 Jan 27;18(1):e258230. doi: 10.1136/bcr-2023-258230.

本文引用的文献

1
Varicella Zoster Meningitis in Immunocompetent Hosts: A Case Series and Review of the Literature.免疫功能正常宿主的水痘带状疱疹性脑膜炎:病例系列及文献综述
WMJ. 2021 Apr;120(1):74-77.
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Herpes Zoster Meningitis in a Young, Immunocompetent Adult.年轻免疫功能正常成人的带状疱疹性脑膜炎。
J Emerg Med. 2021 May;60(5):e99-e101. doi: 10.1016/j.jemermed.2020.12.029. Epub 2021 Feb 10.
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Drug Resistance During HIV Pre-Exposure Prophylaxis.HIV 暴露前预防过程中的耐药性。
Drugs. 2019 Apr;79(6):609-619. doi: 10.1007/s40265-019-01108-x.
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Varicella Zoster aseptic meningitis: Report of an atypical case in an immunocompetent patient treated with oral valacyclovir.水痘带状疱疹性无菌性脑膜炎:1例免疫功能正常患者经口服伐昔洛韦治疗的非典型病例报告。
IDCases. 2018 Aug 25;13:e00446. doi: 10.1016/j.idcr.2018.e00446. eCollection 2018.
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Aseptic and Bacterial Meningitis: Evaluation, Treatment, and Prevention.无菌性和细菌性脑膜炎:评估、治疗与预防
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Aseptic meningitis in adults and children: Diagnostic and management challenges.成人和儿童无菌性脑膜炎:诊断与管理挑战
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The pharmacokinetic basis of oral valacyclovir treatment of herpes simplex virus (HSV) or varicella zoster virus (VZV) meningitis, meningoencephalitis or encephalitis in adults.口服伐昔洛韦治疗成人单纯疱疹病毒(HSV)或水痘带状疱疹病毒(VZV)脑膜炎、脑膜脑炎或脑炎的药代动力学基础。
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Clin Infect Dis. 2013 Oct;57(8):1114-28. doi: 10.1093/cid/cit458. Epub 2013 Jul 15.
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Etiology of aseptic meningitis and encephalitis in an adult population.成年人群无菌性脑膜炎和脑炎的病因
Neurology. 2006 Jan 10;66(1):75-80. doi: 10.1212/01.wnl.0000191407.81333.00.
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Valaciclovir (BW256U87): the L-valyl ester of acyclovir.伐昔洛韦(BW256U87):阿昔洛韦的L-缬氨酸酯。
J Med Virol. 1993;Suppl 1:150-3. doi: 10.1002/jmv.1890410529.