Inamoto Aya, Taniguchi Tomohiro, Fujii Yasumitsu, Miyoshi Sonoko
Hiroshima Prefectural Hospital, Hiroshima, Japan
General Internal Medicine & Infectious Diseases, Hiroshima Prefectural Hospital, Hiroshima, Japan.
BMJ Case Rep. 2025 Jan 27;18(1):e258230. doi: 10.1136/bcr-2023-258230.
Varicella-zoster virus (VZV) is a known cause of meningoencephalitis, typically in immunocompromised inpatients. We report a case of meningitis caused by VZV in an immunocompetent man in his 20s. Diagnosis was delayed due to the atypical presentation of painless occipital zoster mimicking atopic dermatitis, and the presence of hypoglycorrhachia in his cerebrospinal fluid. The clinical diagnosis of VZV meningitis poses significant diagnostic challenges, and nucleic acid tests for VZV detection are recommended for patients with severe cases who require empiric acyclovir treatment.
水痘带状疱疹病毒(VZV)是已知的脑膜脑炎病因,通常发生在免疫功能低下的住院患者中。我们报告一例20多岁免疫功能正常男性由VZV引起的脑膜炎病例。由于无痛性枕部带状疱疹表现不典型,类似特应性皮炎,且脑脊液中存在低糖血症,诊断被延误。VZV脑膜炎的临床诊断面临重大挑战,对于需要经验性使用阿昔洛韦治疗的重症患者,建议进行VZV检测的核酸检测。